UniProt Accession

 B0FLL2_HUMAN; B0FLL2 

Genbank Protein ID

 AL445493; EU334168 

Genbank Nucleotide ID

 ABY59650.1 

Protein Name

 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 transcript variant 3 

Protein Synonyms/Alias

 Fructose-2,6-bisphosphatase 

Gene Name

 PFKFB2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
272	KVWTSQLKRTIQTAE	ubiquitination	[1, 2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 472 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC.
 GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
 GO:0006000; P:fructose metabolic process; IEA:InterPro.
 GO:0006007; P:glucose catabolic process; IEA:Compara.
 GO:0006089; P:lactate metabolic process; IEA:Compara.
 GO:0033133; P:positive regulation of glucokinase activity; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0006090; P:pyruvate metabolic process; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara. 

Interpro

 IPR003094; 6Pfruct_kin.
 IPR013079; 6Phosfructo_kin.
 IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
 IPR013078; His_Pase_superF_clade-1.
 IPR027417; P-loop_NTPase.
 IPR001345; PG/BPGM_mutase_AS. 

Pfam

 PF01591; 6PF2K
 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS

 PR00991; 6PFRUCTKNASE.