UniProt Accession

 ATP5J_RAT; P21571 

Genbank Protein ID

 M73030; X54510; BC059121 

Genbank Nucleotide ID

 AAA40954.1; CAA38369.1; AAH59121.1 

Protein Name

 ATP synthase-coupling factor 6, mitochondrial 

Protein Synonyms/Alias

 ATPase subunit F6 

Gene Name

 Atp5j 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
41	KELDPVQKLFLDKIR	acetylation	[1]
46	VQKLFLDKIREYKAK	acetylation	[1]
51	LDKIREYKAKRLASG	acetylation	[1]
79	DRELFKLKQMYGKGE	acetylation	[1]
84	KLKQMYGKGEMDKFP	acetylation	[1]
89	YGKGEMDKFPTFNFE	acetylation	[1]
99	TFNFEDPKFEVLDKP	acetylation	[1]
105	PKFEVLDKPQS****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes (By similarity). 

Sequence Annotation

 MOD_RES 41 41 N6-acetyllysine (By similarity).
 MOD_RES 46 46 N6-acetyllysine (By similarity).
 MOD_RES 84 84 N6-acetyllysine (By similarity).
 MOD_RES 99 99 N6-acetyllysine (By similarity).
 MOD_RES 105 105 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; CF(0); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IDA:RGD.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0046034; P:ATP metabolic process; IDA:RGD.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR008387; ATPase_F0-cplx_f6su_mt.
 IPR016349; ATPase_F0-cplx_f6su_mt_subgr. 

Pfam

 PF05511; ATP-synt_F6 

SMART

  

PROSITE

  

PRINTS