UniProt Accession

 CBR3_HUMAN; O75828; Q6FHP2 

Genbank Protein ID

 AB004854; AB003151; AB041012; AB124847; CR541709; EF462915; AP000689; AP001725; CH471079; BC002812 

Genbank Nucleotide ID

 BAA33500.1; BAA34207.1; BAD74062.1; BAE45939.1; CAG46510.1; ABO43035.1; BAA89425.1; BAA95547.1; EAX09747.1; AAH02812.1 

Protein Name

 Carbonyl reductase [NADPH] 3 

Protein Synonyms/Alias

 NADPH-dependent carbonyl reductase 3 

Gene Name

 CBR3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	IKAEMTLKTNFFATR	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). 

Sequence Annotation

 NP_BIND 10 34 NADP.
 NP_BIND 38 42 NADP.
 NP_BIND 63 64 NADP.
 NP_BIND 194 198 NADP.
 ACT_SITE 194 194 Proton acceptor (By similarity).
 BINDING 90 90 NADP; via carbonyl oxygen.
 BINDING 140 140 Substrate (By similarity).
 BINDING 239 239 NADP.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000253; F:3-keto sterol reductase activity; IEA:Compara.
 GO:0004090; F:carbonyl reductase (NADPH) activity; IDA:UniProtKB.
 GO:0070402; F:NADPH binding; IDA:UniProtKB.
 GO:0042376; P:phylloquinone catabolic process; IEA:Compara. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.