| Tag | Content |
|---|
| CPLM ID | CPLM-018880 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase N2 |
Protein Synonyms/Alias | R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin |
Gene Name | PTPRN2 |
Gene Synonyms/Alias | KIAA0387 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 970 | NKMAKGAKEIDIAAT | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Implicated in development of nervous system and pancreatic endocrine cells. |
Sequence Annotation | DOMAIN 745 1005 Tyrosine-protein phosphatase.
REGION 945 951 Substrate binding (By similarity).
ACT_SITE 945 945 Phosphocysteine intermediate (By
BINDING 913 913 Substrate (By similarity).
BINDING 990 990 Substrate (By similarity).
MOD_RES 692 692 Phosphoserine (By similarity).
MOD_RES 970 970 N6-acetyllysine.
CARBOHYD 564 564 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Polymorphism; Protein phosphatase; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1015 AA |
Protein Sequence | MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR 60
CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP 120
EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP 180
PAEGDDRFSE SILTYVAHTS ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH 240
HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 300
TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES 360
GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP 420
LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP 480
SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP 540
SSAFADVEVL GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL 600
KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK LSGLGGDPGA 660
DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG PIPSPSARSS ASSWSEEPVQ 720
SNMDISTGHM ILSYMEDHLK NKNRLEKEWE ALCAYQAEPN SSFVAQREEN VPKNRSLAVL 780
TYDHSRVLLK AENSHSHSDY INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV 840
VIVMLTPLAE NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET 900
RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG RSGTYVLIDM 960
VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT AVAEEVNAIL KALPQ 1015 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:Compara. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0030141; C:secretory granule; IEA:Compara. GO:0043195; C:terminal bouton; IEA:Compara. GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell. GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc. GO:0034260; P:negative regulation of GTPase activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |