UniProt Accession

 GSTA4_RAT; P14942 

Genbank Protein ID

 X62660 

Genbank Nucleotide ID

 CAB46530.1 

Protein Name

 Glutathione S-transferase alpha-4 

Protein Synonyms/Alias

 GST 8-8; GST A4-4; GST K; Glutathione S-transferase Yk; GST Yk 

Gene Name

 Gsta4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MEVKPKLYYFQGR	acetylation	[1]
84	AKYNLYGKDLKERVR	acetylation	[1]
87	NLYGKDLKERVRIDM	acetylation	[1]
117	PFKAPQEKEESLALA	acetylation	[1]
126	ESLALAVKRAKNRYF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 3 83 GST N-terminal.
 DOMAIN 85 208 GST C-terminal.
 REGION 54 55 Glutathione binding (By similarity).
 REGION 67 68 Glutathione binding (By similarity).
 BINDING 9 9 Glutathione (By similarity).
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004364; F:glutathione transferase activity; IDA:RGD.
 GO:0071285; P:cellular response to lithium ion; IEP:RGD.
 GO:0009635; P:response to herbicide; IEP:RGD.
 GO:0035094; P:response to nicotine; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0006805; P:xenobiotic metabolic process; IDA:RGD. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR003080; GST_alpha.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01266; GSTRNSFRASEA.