UniProt Accession

 BCAT1_MOUSE; P24288; Q7TMT2 

Genbank Protein ID

 U42443; X17502; BC053706 

Genbank Nucleotide ID

 AAB05673.1; CAA35543.1; AAH53706.1 

Protein Name

 Branched-chain-amino-acid aminotransferase, cytosolic 

Protein Synonyms/Alias

 BCAT(c); Protein ECA39 

Gene Name

 Bcat1 

Gene Synonyms/Alias

 Eca39 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
368	LASRILGKLTDIQYG	acetylation	[1]
368	LASRILGKLTDIQYG	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 222 222 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004084; F:branched-chain-amino-acid transaminase activity; IDA:MGI.
 GO:0052656; F:L-isoleucine transaminase activity; IEA:EC.
 GO:0052654; F:L-leucine transaminase activity; IEA:EC.
 GO:0052655; F:L-valine transaminase activity; IEA:EC.
 GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0009083; P:branched-chain amino acid catabolic process; IDA:MGI.
 GO:0034644; P:cellular response to UV; ISA:MGI.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; ISA:MGI. 

Interpro

 IPR001544; Aminotrans_IV.
 IPR018300; Aminotrans_IV_CS.
 IPR005786; B_amino_transII. 

Pfam

 PF01063; Aminotran_4 

SMART

  

PROSITE

 PS00770; AA_TRANSFER_CLASS_4 

PRINTS