UniProt Accession

 JADE3_HUMAN; Q92613; Q6IE79 

Genbank Protein ID

 AF127774; D86969; Z83822; BC114487; BC113880; BN000289 

Genbank Nucleotide ID

 AAD51905.1; BAA13205.2; AAI14488.1; AAI13881.1; CAE30502.1 

Protein Name

 Protein Jade-3 

Protein Synonyms/Alias

 PHD finger protein 16 

Gene Name

 PHF16 

Gene Synonyms/Alias

 JADE3; KIAA0215 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	SGSMYRIKSKIPNEH	acetylation	[1]
32	SMYRIKSKIPNEHKK	acetylation	[1]
38	SKIPNEHKKPAEVFR	acetylation	[1]
46	KPAEVFRKDLISAMK	ubiquitination	[2]
299	ERMEPITKISHIPPS	acetylation	[3, 4]
318	VCNLCKLKTGACIQC	ubiquitination	[2]
357	LDEGDEVKFKSYCLK	ubiquitination	[2]
371	KHSQNRQKLGEAEYP	acetylation	[5]
383	EYPHHRAKEQSQAKS	acetylation	[4]
389	AKEQSQAKSEKTSLR	acetylation	[4]
461	ENGLVQPKEESIHTR	acetylation	[1, 3, 4]
638	YHGQSLGKPLVLQAA	acetylation	[1, 3, 4, 5]
656	QSSIGNGKSQPNSKF	acetylation	[5]
735	EDLQCYVKPTKNMSP	acetylation	[1, 3, 4, 5]
735	EDLQCYVKPTKNMSP	ubiquitination	[5]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. 

Sequence Annotation

 ZN_FING 200 250 PHD-type.
 MOD_RES 30 30 N6-acetyllysine.
 MOD_RES 32 32 N6-acetyllysine.
 MOD_RES 38 38 N6-acetyllysine.
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 566 566 Phosphoserine.
 MOD_RES 638 638 N6-acetyllysine.
 MOD_RES 774 774 Phosphoserine.
 MOD_RES 776 776 Phosphoserine.
 MOD_RES 780 780 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 823 AA 

Protein Sequence

Gene Ontology

 GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
 GO:0043983; P:histone H4-K12 acetylation; IDA:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB. 

Interpro

 IPR019542; Enhancer_polycomb-like_N.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF10513; EPL1
 PF00628; PHD 

SMART

 SM00249; PHD 

PROSITE

 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 

PRINTS