CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015046
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Holliday junction ATP-dependent DNA helicase RuvA 
Protein Synonyms/Alias
  
Gene Name
 ruvA 
Gene Synonyms/Alias
 RPA1100 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
131IVTELKDKVPALSAVacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; SOS response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 205 AA 
Protein Sequence
MIGKLKGIID SYGEDYVILD VQGVGYQVHC ASRTLQALPS PGEAATLSIE TYVREDQIKL 60
FGFRTDTERE WFRLLQTVQS VGAKVALAVL STLPPHDLAN AIALRDKAAV ARTPGVGPKV 120
AERIVTELKD KVPALSAVDP AVVKLSGAID DNRAPRAVAD AISALVNLGY GQPQAAAAVA 180
TASRTAGEDA ETAQLIKLGL KELSK 205 
Gene Ontology
 GO:0009379; C:Holliday junction helicase complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0009378; F:four-way junction helicase activity; IEA:InterPro.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0009432; P:SOS response; IEA:UniProtKB-KW. 
Interpro
 IPR011114; DNA_helicas_Holl-junc_RuvA_C.
 IPR013849; DNA_helicase_Holl-junc_RuvA_I.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR012340; NA-bd_OB-fold.
 IPR000085; RuvA.
 IPR010994; RuvA_2-like. 
Pfam
 PF07499; RuvA_C
 PF01330; RuvA_N 
SMART
 SM00278; HhH1 
PROSITE
  
PRINTS