Tag | Content |
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CPLM ID | CPLM-024653 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase beta |
Protein Synonyms/Alias | Protein-tyrosine phosphatase beta; R-PTP-beta; Vascular endothelial protein tyrosine phosphatase; VE-PTP |
Gene Name | Ptprb |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1675 | VHLNLGQKGNRKTSC | ubiquitination | [1] | 1695 | QFEGHFMKLQADSNY | ubiquitination | [1] | 1746 | PYDASRVKLCNVDDD | ubiquitination | [1] | 1969 | RDVLRAKKLRNEQEN | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. |
Sequence Annotation | DOMAIN 23 109 Fibronectin type-III 1. DOMAIN 111 202 Fibronectin type-III 2. DOMAIN 204 289 Fibronectin type-III 3. DOMAIN 290 376 Fibronectin type-III 4. DOMAIN 378 466 Fibronectin type-III 5. DOMAIN 468 553 Fibronectin type-III 6. DOMAIN 555 642 Fibronectin type-III 7. DOMAIN 644 731 Fibronectin type-III 8. DOMAIN 732 818 Fibronectin type-III 9. DOMAIN 820 907 Fibronectin type-III 10. DOMAIN 908 994 Fibronectin type-III 11. DOMAIN 996 1084 Fibronectin type-III 12. DOMAIN 1086 1173 Fibronectin type-III 13. DOMAIN 1174 1261 Fibronectin type-III 14. DOMAIN 1262 1354 Fibronectin type-III 15. DOMAIN 1356 1444 Fibronectin type-III 16. DOMAIN 1449 1551 Fibronectin type-III 17. DOMAIN 1704 1964 Tyrosine-protein phosphatase. REGION 1905 1911 Substrate binding (By similarity). ACT_SITE 1905 1905 Phosphocysteine intermediate (By BINDING 1871 1871 Substrate (By similarity). BINDING 1949 1949 Substrate (By similarity). CARBOHYD 28 28 N-linked (GlcNAc...) (Potential). CARBOHYD 53 53 N-linked (GlcNAc...) (Potential). CARBOHYD 75 75 N-linked (GlcNAc...) (Potential). CARBOHYD 173 173 N-linked (GlcNAc...) (Potential). CARBOHYD 199 199 N-linked (GlcNAc...) (Potential). CARBOHYD 268 268 N-linked (GlcNAc...) (Potential). CARBOHYD 415 415 N-linked (GlcNAc...) (Potential). CARBOHYD 422 422 N-linked (GlcNAc...) (Potential). CARBOHYD 480 480 N-linked (GlcNAc...) (Potential). CARBOHYD 575 575 N-linked (GlcNAc...) (Potential). CARBOHYD 599 599 N-linked (GlcNAc...) (Potential). CARBOHYD 653 653 N-linked (GlcNAc...) (Potential). CARBOHYD 830 830 N-linked (GlcNAc...) (Potential). CARBOHYD 1041 1041 N-linked (GlcNAc...) (Potential). CARBOHYD 1097 1097 N-linked (GlcNAc...) (Potential). CARBOHYD 1164 1164 N-linked (GlcNAc...) (Potential). CARBOHYD 1186 1186 N-linked (GlcNAc...) (Potential). CARBOHYD 1213 1213 N-linked (GlcNAc...) (Potential). CARBOHYD 1275 1275 N-linked (GlcNAc...) (Potential). CARBOHYD 1368 1368 N-linked (GlcNAc...) (Potential). CARBOHYD 1471 1471 N-linked (GlcNAc...) (Potential). CARBOHYD 1475 1475 N-linked (GlcNAc...) (Potential). CARBOHYD 1519 1519 N-linked (GlcNAc...) (Potential). |
Keyword | Angiogenesis; Complete proteome; Glycoprotein; Hydrolase; Membrane; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1998 AA |
Protein Sequence | MLRHGALTAL WITLSVVQTG VAEQVKCNFT LLESRVSSLS ASIQWRTFAS PCNFSLIYSS 60 DTSGPMWCHP IRIDNFTYGC NPKDLQAGTV YNFRIVSLDG EESTLVLQTD PLPPARFEVN 120 REKTASTTLQ VRWTPSSGKV SWYEVQLFDH NNQKIQEVQV QESTTWSQYT FLNLTEGNSY 180 KVAITAVSGE KRSFPVYING STVPSPVKDL GISPNPNSLL ISWSRGSGNV EQYRLVLMDK 240 GAIVQDTNVD RRDTSYAFHE LTPGHLYNLT IVTMASGLQN SRWKLVRTAP MEVSNLKVTN 300 DGRLTSLNVK WQKPPGDVDS YSITLSHQGT IKESKTLAPP VTETQFKDLV PGRLYQVTIS 360 CISGELSAEK SAAGRTVPEK VRNLVSYNEI WMKSFTVNWT PPAGDWEHYR IVLFNESLVL 420 LNTTVGKEET HYALDGLELI PGRQYEIEVI VESGNLRNSE RCQGRTVPLA VLQLRVKHAN 480 ETSLGITWRA PLGEWEKYII SLMDRELLVI HKSLSKDAKE FTFTDLMPGR NYKATVTSMS 540 GDLKQSSSIK GRTVPAQVTD LHVNNQGMTS SLFTNWTKAL GDVEFYQVLL IHENVVVKNE 600 SVSSDTSRYS FRALKPGSLY SVVVTTVSGG ISSRQVVAEG RTVPSSVSGV TVNNSGRNDY 660 LSVSWLPAPG EVDHYVVSLS HEGKVDQFLI IAKSVSECSF SSLTPGRLYN VTVTTKSGNY 720 ASHSFTEERT VPDKVQGISV SNSARSDYLK VSWVHATGDF DHYEVTIKNR ESFIQTKTIP 780 KSENECEFIE LVPGRLYSVT VSTKSGQYEA SEQGTGRTIP EPVKDLTLLN RSTEDLHVTW 840 SRANGDVDQY EVQLLFNDMK VFPHIHLVNT ATEYKFTALT PGRHYKILVL TISGDVQQSA 900 FIEGLTVPST VKNIHISANG ATDRLMVTWS PGGGDVDSYV VSAFRQDEKV DSQTIPKHAS 960 EHTFHRLEAG AKYRIAIVSV SGSLRNQIDA LGQTVPASVQ GVVAANAYSS NSLTVSWQKA 1020 LGVAERYDIL LLNENGLLLS NVSEPATARQ HKFEDLTPGK KYKMQILTVS GGLFSKESQA 1080 EGRTVPAAVT NLRITENSSR YLSFGWTASE GELSWYNIFL YNPDRTLQER AQVDPLVQSF 1140 SFQNLLQGRM YKMVIVTHSG ELSNESFIFG RTVPAAVNHL KGSHRNTTDS LWFSWSPASG 1200 DFDFYELILY NPNGTKKENW KEKDVTEWRF QGLVPGRKYT LYVVTHSGDL SNKVTGEGRT 1260 APSPPSLLSF ADVANTSLAI TWKGPPDWTD YNDFELQWFP GDALTIFNPY SSRKSEGRIV 1320 YGLHPGRSYQ FSVKTVSGDS WKTYSKPISG SVRTKPDKIQ NLHCRPQNST AIACSWIPPD 1380 SDFDGYSIEC RKMDTQEIEF SRKLEKEKSL LNIMMLVPHK RYLVSIKVQS AGMTSEVVED 1440 STITMIDRPP QPPPHIRVNE KDVLISKSSI NFTVNCSWFS DTNGAVKYFA VVVREADSMD 1500 ELKPEQQHPL PSYLEYRHNA SIRVYQTNYF ASKCAESPDS SSKSFNIKLG AEMDSLGGKC 1560 DPSQQKFCDG PLKPHTAYRI SIRAFTQLFD EDLKEFTKPL YSDTFFSMPI TTESEPLFGV 1620 IEGVSAGLFL IGMLVALVAF FICRQKASHS RERPSARLSI RRDRPLSVHL NLGQKGNRKT 1680 SCPIKINQFE GHFMKLQADS NYLLSKEYED LKDVGRSQSC DIALLPENRG KNRYNNILPY 1740 DASRVKLCNV DDDPCSDYIN ASYIPGNNFR REYIATQGPL PGTKDDFWKM AWEQNVHNIV 1800 MVTQCVEKGR VKCDHYWPAD QDPLYYGDLI LQMVSESVLP EWTIREFKIC SEEQLDAHRL 1860 IRHFHYTVWP DHGVPETTQS LIQFVRTVRD YINRSPGAGP TVVHCSAGVG RTGTFVALDR 1920 ILQQLDSKDS VDIYGAVHDL RLHRVHMVQT ECQYVYLHQC VRDVLRAKKL RNEQENPLFP 1980 IYENVNPEYH RDAIYSRH 1998 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. GO:0001525; P:angiogenesis; IDA:UniProtKB. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |