| Tag | Content |
|---|
| CPLM ID | CPLM-008678 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Antiviral helicase SLH1 |
Protein Synonyms/Alias | SKI2-like helicase 1 |
Gene Name | SLH1 |
Gene Synonyms/Alias | YGR271W; G9365 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1207 | ERVDDWRKKITPVTG | ubiquitination | [1] | | 1208 | RVDDWRKKITPVTGD | ubiquitination | [1] |
|
Reference | [1] Identification, analysis, and prediction of protein ubiquitination sites. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. Proteins. 2010 Feb 1;78(2):365-80. [ PMID: 19722269] |
Functional Description | Together with SKI2, represses the translation of non- poly(A) mRNAs. May block translation by inhibiting translation initiation factor 5B (FUN12) action on mRNAs lacking a 3' poly(A) structure. Involved in antiviral defense, preventing L-A dsRNA virus propagation by specifically blocking translation of viral mRNAs. |
Sequence Annotation | DOMAIN 297 485 Helicase ATP-binding 1.
DOMAIN 516 735 Helicase C-terminal 1.
DOMAIN 795 1100 SEC63 1.
DOMAIN 1149 1324 Helicase ATP-binding 2.
DOMAIN 1355 1550 Helicase C-terminal 2.
DOMAIN 1626 1776 SEC63 2.
NP_BIND 310 317 ATP (Potential).
NP_BIND 1162 1169 ATP (By similarity).
MOTIF 427 430 DEVH box.
MOTIF 1266 1269 DEAH box. |
Keyword | Antiviral defense; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; Nucleotide-binding; Reference proteome; Repeat; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1967 AA |
Protein Sequence | MSTEYSADSS KSFMIAMQSM IDTSQTFNLD RSKISLPDFD DELKKVQKDE QNQRTELTVL 60
SQDRNDWDDI FEEFKDISFA QLQSIIDSYK TKNAVAVYKK IGKLINEAET TLSSNVLLET 120
VLQMVYKHQK QELEKELLDF LGTGNIDLVS LLLQHRRMIV ATPIETTILL IKNAVNSTPE 180
FLTQQDIRNQ VLKSAEDAKN RKLNPATKII KYPHVFRKYE AGSTTAMAFA GQKFTLPVGT 240
TRMSYNTHEE IIIPAADQAS NKNYLYTKLL KISDLDHFCK TVFPYETLNQ IQSLVYPVAY 300
KTNENMLICA PTGAGKTDIA LLTIINTIKQ FSVVNGENEI DIQYDDFKVI YVAPLKALAA 360
EIVDKFSKKL APFNIQVREL TGDMQLTKAE ILATQVIVTT PEKWDVVTRK ANGDNDLVSK 420
VKLLIIDEVH LLHEDRGSVI ETLVARTLRQ VESSQSMIRI IGLSATLPNF MDVADFLGVN 480
RQIGMFYFDQ SFRPKPLEQQ LLGCRGKAGS RQSKENIDKV AYDKLSEMIQ RGYQVMVFVH 540
SRKETVKSAR NFIKLAESNH EVDLFAPDPI EKDKYSRSLV KNRDKDMKEI FQFGFGIHHA 600
GMARSDRNLT EKMFKDGAIK VLCCTATLAW GVNLPADCVI IKGTQVYDSK KGGFIDLGIS 660
DVIQIFGRGG RPGFGSANGT GILCTSNDRL DHYVSLITQQ HPIESRFGSK LVDNLNAEIS 720
LGSVTNVDEA IEWLGYTYMF VRMRKNPFTY GIDWEEIAND PQLYERRRKM IVVAARRLHA 780
LQMIVFDEVS MHFIAKDLGR VSSDFYLLNE SVEIFNQMCD PRATEADVLS MISMSSEFDG 840
IKFREEESKE LKRLSDESVE CQIGSQLDTP QGKANVLLQA YISQTRIFDS ALSSDSNYVA 900
QNSVRICRAL FLIGVNRRWG KFSNVMLNIC KSIEKRLWAF DHPLCQFDLP ENIIRRIRDT 960
KPSMEHLLEL EADELGELVH NKKAGSRLYK ILSRFPKINI EAEIFPITTN VMRIHIALGP 1020
DFVWDSRIHG DAQFFWVFVE ESDKSQILHF EKFILNRRQL NNQHEMDFMI PLSDPLPPQV 1080
VVKVVSDTWI GCESTHAISF QHLIRPFNET LQTKLLKLRP LPTSALQNPL IESIYPFKYF 1140
NPMQTMTFYT LYNTNENAFV GSPTGSGKTI VAELAIWHAF KTFPGKKIVY IAPMKALVRE 1200
RVDDWRKKIT PVTGDKVVEL TGDSLPDPKD VHDATIVITT PEKFDGISRN WQTRKFVQDV 1260
SLIIMDEIHL LASDRGPILE MIVSRMNYIS SQTKQPVRLL GMSTAVSNAY DMAGWLGVKD 1320
HGLYNFPSSV RPVPLKMYID GFPDNLAFCP LMKTMNKPVF MAIKQHSPDK PALIFVASRR 1380
QTRLTALDLI HLCGMEDNPR RFLNIDDEEE LQYYLSQVTD DTLKLSLQFG IGLHHAGLVQ 1440
KDRSISHQLF QKNKIQILIA TSTLAWGVNL PAHLVIIKGT QFFDAKIEGY RDMDLTDILQ 1500
MMGRAGRPAY DTTGTAIVYT KESKKMFYKH FLNVGFPVES SLHKVLDDHL GAEITSGSIT 1560
NKQEALDFLS WTFLFRRAHH NPTYYGIEDD TSTAGVSEHL SSLIDSTLEN LRESQCVLLH 1620
GDDIVATPFL SISSYYYISH LTIRQLLKQI HDHATFQEVL RWLSLAVEYN ELPVRGGEII 1680
MNEEMSQQSR YSVESTFTDE FELPMWDPHV KTFLLLQAHL SRVDLPIADY IQDTVSVLDQ 1740
SLRILQAYID VASELGYFHT VLTMIKMMQC IKQGYWYEDD PVSVLPGLQL RRIKDYTFSE 1800
QGFIEMTPQQ KKKKLLTLEE IGRFGYKKLL NVFDQLTFGM TESEDTKKRF VSVCQRLPVL 1860
EGMKFEEQEN NEVLTFYSKH LSSKHNNGFE VYCDKFPKIQ KELWFLIGHK GDELLMIKRC 1920
QPKQMNKEVI IHCDLFIPEE IRGEELQFSL INDALGLRYD MVHKLIS 1967 |
Gene Ontology | |
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