UniProt Accession

 IMMT_HUMAN; Q16891; B1H0U5; B2R5N6; Q14539; Q15092; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2 

Genbank Protein ID

 D21091; D21092; D21093; D21094; L42572; CR456793; AK312251; AY232292; AY921637; BX537369; CR749590; BC002412; BC027458; AF148646 

Genbank Nucleotide ID

 BAA04653.1; BAA04654.1; BAA04655.1; BAA04656.1; AAA85336.1; CAG33074.1; BAG35183.1; AAP69987.1; AAX10024.1; CAD97612.1; CAH18389.1; AAH02412.1; AAH27458.1; AAF73126.1 

Protein Name

 Mitochondrial inner membrane protein 

Protein Synonyms/Alias

 Cell proliferation-inducing gene 4/52 protein; Mitofilin; p87/89 

Gene Name

 IMMT 

Gene Synonyms/Alias

 HMP; MINOS2; PIG4; PIG52 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	AYNVPLPKKSIQSGP	ubiquitination	[1, 2]
102	YNVPLPKKSIQSGPL	ubiquitination	[3]
110	SIQSGPLKISSVSEV	ubiquitination	[1, 2]
119	SSVSEVMKESKQPAS	ubiquitination	[3]
211	ARLAQQEKQEQVKIE	acetylation	[4]
222	VKIESLAKSLEDALR	acetylation	[4]
270	SEIAGEKKSAQWRTV	ubiquitination	[3]
282	RTVEGALKERRKAVD	ubiquitination	[3]
451	AFDSAVAKALEHHRS	acetylation	[4]
451	AFDSAVAKALEHHRS	ubiquitination	[1, 2, 3, 5, 6]
506	RVQEQELKSEFEQNL	ubiquitination	[5]
516	FEQNLSEKLSEQELQ	ubiquitination	[3, 5]
581	EALKYSMKTSSAETP	ubiquitination	[3, 5]
640	ARFYAVQKLARRVAM	ubiquitination	[1, 2, 3]
714	AKFVNQLKGESRRVA	ubiquitination	[3]
726	RVAQDWLKEARMTLE	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

 MOD_RES 211 211 N6-acetyllysine.
 MOD_RES 222 222 N6-acetyllysine.
 MOD_RES 451 451 N6-acetyllysine.
 MOD_RES 506 506 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 758 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
 GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara. 

Interpro

 IPR019133; Mt-IM_prot_Mitofilin. 

Pfam

 PF09731; Mitofilin 

SMART

  

PROSITE

  

PRINTS