CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032148
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ56016, highly similar to C-1-tetrahydrofolate synthase, cytoplasmic 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
426LKHRPDGKYVVVTGIubiquitination[1]
529HELTQTDKALFNRLVubiquitination[1]
644DMRERLGKMVVASSKubiquitination[1]
840HGAFDAVKCTHWAEGubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1020 AA 
Protein Sequence
MRHRVCRGRS GQGRRRSSVI PRPVPKHVGW VVLLGCGGSG TSILVVSIVG SGLIKAMAPA 60
EILNGKEISA QIRARLKNQV TQLKEQVPGF TPRLAILQVG NRDDSNLYIN VKLKAAEEIG 120
IKATHIKLPR TTTESEVMKY ITSLNEDSTV HGFLVQLPLD SENSINTEEV INAIAPEKDV 180
DGLTSINAGK LARGDLNDCF IPCTPKGCLE LIKETGVPIA GRHAVVVGRS KIVGAPMHDL 240
LLWNNATVTT CHSKTAHLDE EVNKGDVLVV ATGQPEMVKG EWIKPGAIVI DCGINYVPDD 300
KKPNGRKVVG DVAYDEAKER ASFITPVPGG VGPMTVAMLM QSTVESAKRF LEKFKPGKWM 360
IQYNNLNLKT PVPSDIDISR SCKPKPIGKL AREIGLLSEE VELYGETKAK VLLSALERLK 420
HRPDGKYVVV TGITPTPLGE GKSTTTIGLV QALGAHLYQN VFACVRQPSQ GPTFGIKGGA 480
AGGGYSQVIP MEEFNLHLTG DIHAITAANN LVAAAIDARI FHELTQTDKA LFNRLVPSVN 540
GVRRFSDIQI RRLKRLGIEK TDPTTLTDEE INRFARLDID PETITWQRVL DTNDRFLRKI 600
TIGQAPTEKG HTRTAQFDIS VASEIMAVLA LTTSLEDMRE RLGKMVVASS KKGEPVSAED 660
LGVSGALTVL MKDAIKPNLM QTLEGTPVFV HAGPFANIAH GNSSIIADRI ALKLVGPEGF 720
VVTGAGFGAD IGMEKFFNIK CRYSGLCPHV VVLVATVRAL KMHGGGPTVT AGLPLPKAYI 780
QENLELVEKG FSNLKKQIEN ARMFGIPVVV AVNAFKTDTE SELDLISRLS REHGAFDAVK 840
CTHWAEGGKG ALALAQAVQR AAQAPSSFQL LYDLKLPVED KIRIIAQKIY GADDIELLPE 900
AQHKAEVYTK QGFGNLPICM AKTHLSLSHN PEQKGVPTGF ILPIRDIRAS VGAGFLYPLV 960
GTITIHLQEA TLKVWPVSIQ AHWELGSISK PREVSPCPED LKLIVGVSPE VIFSLNSHHV 1020 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:InterPro.
 GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro. 
Interpro
 IPR000559; Formate_THF_ligase.
 IPR020628; Formate_THF_ligase_CS.
 IPR016040; NAD(P)-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR000672; THF_DH/CycHdrlase.
 IPR020630; THF_DH/CycHdrlase_cat_dom.
 IPR020867; THF_DH/CycHdrlase_CS.
 IPR020631; THF_DH/CycHdrlase_NAD-bd_dom. 
Pfam
 PF01268; FTHFS
 PF00763; THF_DHG_CYH
 PF02882; THF_DHG_CYH_C 
SMART
  
PROSITE
 PS00721; FTHFS_1
 PS00722; FTHFS_2
 PS00766; THF_DHG_CYH_1
 PS00767; THF_DHG_CYH_2 
PRINTS
 PR00085; THFDHDRGNASE.