| Tag | Content |
|---|
| CPLM ID | CPLM-023862 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosomal biogenesis protein LAS1L |
Protein Synonyms/Alias | Protein LAS1 homolog |
Gene Name | LAS1L |
Gene Synonyms/Alias | MSTP060 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 469 | QLLRIIFKAMGQGLP | ubiquitination | [1] | | 523 | DSLYWSVKPASSSFG | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. |
Sequence Annotation | MOD_RES 523 523 Phosphoserine.
MOD_RES 560 560 Phosphoserine.
MOD_RES 617 617 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 734 AA |
Protein Sequence | MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC 60
DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV 120
RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL 180
QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV 240
KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP 300
SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEENV DLNDVLVPKP 360
FSQFWQPLLR GLHSQNFTQA LLERMLSELP ALGISGIRPT YILRWTVELI VANTKTGRNA 420
RRFSAGQWEA RRGWRLFNCS ASLDWPRMVE SCLGSPCWAS PQLLRIIFKA MGQGLPDEEQ 480
EKLLRICSIY TQSGENSLVQ EGSEASPIGK SPYTLDSLYW SVKPASSSFG SEAKAQQQEE 540
QGSVNDVKEE EKEEKEVLPD QVEEEEENDD QEEEEEDEDD EDDEEEDRME VGPFSTGQES 600
PTAENARLLA QKRGALQGSA WQVSSEDVRW DTFPLGRMPG QTEDPAELML ENYDTMYLLD 660
QPVLEQRLEP STCKTDTLGL SCGVGSGNCS NSSSSNFEGL LWSQGQLHGL KTGLQLF 717 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |