UniProt Accession

 CASQ1_MOUSE; O09165 

Genbank Protein ID

 U93291; AC074310 

Genbank Nucleotide ID

 AAC63616.1 

Protein Name

 Calsequestrin-1 

Protein Synonyms/Alias

 Calsequestrin, skeletal muscle isoform 

Gene Name

 Casq1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	RVINVNAKNYKNVFK	ubiquitination	[1]
79	HEPPEDDKASQRQFE	ubiquitination	[1]
113	FGLVDSEKDAAVAKK	ubiquitination	[1]
187	IKLIGYFKSKDSEHY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). 

Sequence Annotation

 MOD_RES 387 387 Phosphothreonine (By similarity).
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Complete proteome; Glycoprotein; Muscle protein; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 405 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0031674; C:I band; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0033018; C:sarcoplasmic reticulum lumen; IDA:MGI.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0014804; C:terminal cisterna lumen; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007029; P:endoplasmic reticulum organization; IMP:MGI.
 GO:0051282; P:regulation of sequestering of calcium ion; IEA:Compara.
 GO:0014809; P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; IMP:MGI.
 GO:0014894; P:response to denervation involved in regulation of muscle adaptation; IEA:Compara.
 GO:0009408; P:response to heat; IMP:MGI.
 GO:0010033; P:response to organic substance; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara. 

Interpro

 IPR001393; Calsequestrin.
 IPR018233; Calsequestrin_CS.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF01216; Calsequestrin 

SMART

  

PROSITE

 PS00863; CALSEQUESTRIN_1
 PS00864; CALSEQUESTRIN_2 

PRINTS

 PR00312; CALSEQUESTRN.