CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LON peptidase N-terminal domain and RING finger protein 1 
Protein Synonyms/Alias
 RING finger protein 191 
Gene Name
 LONRF1 
Gene Synonyms/Alias
 RNF191 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
203VLNHLAEKWFPGQREmethylation[1]
203VLNHLAEKWFPGQREubiquitination[2]
333LLLPENLKEGLKESSubiquitination[2]
409PAREDCLKRVSSEPVubiquitination[2]
429KGVLLKRKLSLLEQDubiquitination[2]
500PCGHSFCKNCLERCLubiquitination[2]
645VVDTVGGKRFRVLKRubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 REPEAT 48 81 TPR 1.
 REPEAT 212 244 TPR 2.
 REPEAT 246 278 TPR 3.
 REPEAT 279 312 TPR 4.
 DOMAIN 567 766 Lon.
 ZN_FING 123 159 RING-type 1.
 ZN_FING 479 517 RING-type 2.  
Keyword
 Alternative splicing; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Repeat; TPR repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 773 AA 
Protein Sequence
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL LLRRGELLAL 60
GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR HGLGWSAAPV AGADGGAGGL 120
LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE LRARCRLCRD RLPPATASAT DAEGTAPRPP 180
PLAAAIAASD FRTSVVLNHL AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA 240
EPSDLIVKIY RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ 300
LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR PFDFHSVMEE 360
SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE MPAREDCLKR VSSEPVLSVQ 420
EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ GETPNEVCMF SLAYGDIPEE LIDVSDFECS 480
LCMRLFFEPV TTPCGHSFCK NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV 540
KYLPDELSER KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ 600
TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL KRGMKDGYCT 660
ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD RFRSQILQHF GSMPEREENL 720
QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM KSLKERLTKI QHILTYFSRD QSK 773 
Gene Ontology
 GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR003111; Pept_S16_N.
 IPR015947; PUA-like_domain.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02190; LON
 PF07719; TPR_2
 PF00097; zf-C3HC4 
SMART
 SM00184; RING
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS