CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001057
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha 
Protein Synonyms/Alias
 PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha 
Gene Name
 Ppargc1a 
Gene Synonyms/Alias
 Pgc1; Pgc1a; Ppargc1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
183RTNPAIVKTENSWSNsumoylation[1]
Reference
 [1] SUMOylation attenuates the function of PGC-1alpha.
 Rytinki MM, Palvimo JJ.
 J Biol Chem. 2009 Sep 18;284(38):26184-93. [PMID: 19625249] 
Functional Description
 Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. 
Sequence Annotation
 DOMAIN 676 752 RRM.
 REGION 292 338 Interaction with PPARG (By similarity).
 MOTIF 142 146 LXXLL motif.
 MOD_RES 77 77 N6-acetyllysine.
 MOD_RES 144 144 N6-acetyllysine.
 MOD_RES 177 177 Phosphothreonine; by AMPK.
 MOD_RES 183 183 N6-acetyllysine.
 MOD_RES 253 253 N6-acetyllysine.
 MOD_RES 270 270 N6-acetyllysine.
 MOD_RES 277 277 N6-acetyllysine.
 MOD_RES 320 320 N6-acetyllysine.
 MOD_RES 346 346 N6-acetyllysine.
 MOD_RES 412 412 N6-acetyllysine.
 MOD_RES 441 441 N6-acetyllysine.
 MOD_RES 450 450 N6-acetyllysine.
 MOD_RES 538 538 Phosphoserine; by AMPK.
 MOD_RES 757 757 N6-acetyllysine.
 MOD_RES 778 778 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 797 AA 
Protein Sequence
MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL GGLKWCSDQS 60
EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD EDGLPSFDAL TDGAVTTDNE 120
ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA NTQLSYNECS GLSTQNHAAN HTHRIRTNPA 180
IVKTENSWSN KAKSICQQQK PQRRPCSELL KYLTTNDDPP HTKPTENRNS SRDKCASKKK 240
SHTQPQSQHA QAKPTTLSLP LTPESPNDPK GSPFENKTIE RTLSVELSGT AGLTPPTTPP 300
HKANQDNPFK ASPKLKPSCK TVVPPPTKRA RYSECSGTQG SHSTKKGPEQ SELYAQLSKS 360
SGLSRGHEER KTKRPSLRLF GDHDYCQSLN SKTDILINIS QELQDSRQLD FKDASCDWQG 420
HICSSTDSGQ CYLRETLEAS KQVSPCSTRK QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT 480
SELRDGDFSN EQFSKLPVFI NSGLAMDGLF DDSEDESDKL SYPWDGTQPY SLFDVSPSCS 540
SFNSPCRDSV SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY 600
YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR KEHEKRESER 660
AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG EIEECTVNLR DDGDSYGFIT 720
YRYTCDAFAA LENGYTLRRS NETDFELYFC GRKQFFKSNY ADLDTNSDDF DPASTKSKYD 780
SLDFDSLLKE AQRSLRR 797 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0031490; F:chromatin DNA binding; IDA:MGI.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003713; F:transcription coactivator activity; IMP:UniProtKB.
 GO:0034599; P:cellular response to oxidative stress; IMP:MGI.
 GO:0007005; P:mitochondrion organization; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0070997; P:neuron death; ISS:UniProtKB.
 GO:2001171; P:positive regulation of ATP biosynthetic process; IMP:UniProtKB.
 GO:1901857; P:positive regulation of cellular respiration; IMP:UniProtKB.
 GO:2000507; P:positive regulation of energy homeostasis; IMP:UniProtKB.
 GO:0046321; P:positive regulation of fatty acid oxidation; IEA:Compara.
 GO:1901860; P:positive regulation of mitochondrial DNA metabolic process; IMP:UniProtKB.
 GO:0010822; P:positive regulation of mitochondrion organization; IMP:UniProtKB.
 GO:1901863; P:positive regulation of muscle tissue development; IMP:UniProtKB.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; IDA:MGI.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0014850; P:response to muscle activity; IMP:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS