CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase ITK/TSK 
Protein Synonyms/Alias
  
Gene Name
 ITK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13RCCSQLEKLATGCAQubiquitination[1, 2]
25CAQYDPTKNASKKPLubiquitination[1, 2]
29DPTKNASKKPLPPTPubiquitination[2, 3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 73 AA 
Protein Sequence
MDGKWRCCSQ LEKLATGCAQ YDPTKNASKK PLPPTPEDNR RPLWEPEETV VIALYDYQTN 60
DPQELALRRN EEY 73 
Gene Ontology
 GO:0032609; P:interferon-gamma production; IEA:Compara.
 GO:0032633; P:interleukin-4 production; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0001865; P:NK T cell differentiation; IEA:Compara. 
Interpro
 IPR001562; Znf_Btk_motif. 
Pfam
 PF00779; BTK 
SMART
 SM00107; BTK 
PROSITE
 PS51113; ZF_BTK 
PRINTS