UniProt Accession

 K7EJT4_HUMAN; K7EJT4 

Genbank Protein ID

 AC090241; AC090373 

Genbank Nucleotide ID

  

Protein Name

 E3 SUMO-protein ligase PIAS2 

Protein Synonyms/Alias

  

Gene Name

 PIAS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	GRNKSGRKHDLLMRA	ubiquitination	[1]
37	MRALHLLKSGCSPAV	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 122 AA 

Protein Sequence

Gene Ontology

 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0019789; F:SUMO ligase activity; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045667; P:regulation of osteoblast differentiation; IEA:Compara. 

Interpro

 IPR027228; PIAS2.
 IPR003034; SAP_dom. 

Pfam

  

SMART

 SM00513; SAP 

PROSITE

 PS50800; SAP 

PRINTS