UniProt Accession

 HNRH1_MOUSE; O35737 

Genbank Protein ID

 Y14196; BC056224 

Genbank Nucleotide ID

 CAA74583.1; AAH56224.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein H 

Protein Synonyms/Alias

 hnRNP H; Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 

Gene Name

 Hnrnph1 

Gene Synonyms/Alias

 Hnrph; Hnrph1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	QRFFSDCKIQNGAQG	ubiquitination	[1]
185	HRYIEIFKSSRAEVR	acetylation	[2, 3]
349	VAAMSKDKANMQHRY	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity). 

Sequence Annotation

 DOMAIN 11 90 RRM 1.
 DOMAIN 111 188 RRM 2.
 REPEAT 234 249 1-1.
 DOMAIN 289 364 RRM 3.
 REPEAT 354 372 2-1.
 REPEAT 374 392 2-2.
 REPEAT 418 433 1-2.
 REGION 234 433 2 X 16 AA Gly-rich approximate repeats.
 REGION 354 392 2 X 19 AA perfect repeats.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylmethionine; in Heterogeneous
 MOD_RES 23 23 Phosphoserine (By similarity).
 MOD_RES 63 63 Phosphoserine (By similarity).
 MOD_RES 104 104 Phosphoserine.
 MOD_RES 107 107 Phosphothreonine (By similarity).
 MOD_RES 233 233 Dimethylated arginine; alternate (By
 MOD_RES 233 233 Omega-N-methylarginine; alternate (By
 MOD_RES 246 246 Phosphotyrosine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 449 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR012996; Znf_CHHC. 

Pfam

 PF08080; zf-RNPHF 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS