CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021321
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 106 
Protein Synonyms/Alias
 Zfp-106; Zinc finger protein 474 
Gene Name
 ZNF106 
Gene Synonyms/Alias
 SH3BP3; ZFP106; ZNF474 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136QRDWKWEKDGFNNTRubiquitination[1]
243NYSGPGDKFQPGRNRubiquitination[1, 2, 3, 4]
287WQRQENDKLGTVATYubiquitination[1]
356WTPYPSQKTLDLQSGubiquitination[1, 2, 4]
539NDTLRKAKEVLQCHEubiquitination[1]
557NPLLSTSKSTRNYAKubiquitination[1]
650CNPIVRQKESELQMTubiquitination[1]
721PLLPELSKLGFPASLubiquitination[1]
770HRKSETEKESGLKPTubiquitination[1]
775TEKESGLKPTLRQILubiquitination[1]
800QVIQQVTKKKQELGKubiquitination[1]
801VIQQVTKKKQELGKGubiquitination[1]
807KKKQELGKGLPRFGIubiquitination[1]
905LRAGQSQKATMHLKQubiquitination[1]
1265HEPSQELKFSVEQRNsumoylation[5]
1486SEIGTRYKDGIPVSVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions.
 Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenschuh H, Thibault P.
 Mol Cell Proteomics. 2013 Jun 7;. [PMID: 23750026
Functional Description
  
Sequence Annotation
 REPEAT 1529 1568 WD 1.
 REPEAT 1570 1611 WD 2.
 REPEAT 1654 1695 WD 3.
 REPEAT 1698 1737 WD 4.
 REPEAT 1738 1775 WD 5.
 REPEAT 1778 1815 WD 6.
 ZN_FING 20 44 C2H2-type 1; atypical.
 ZN_FING 1813 1838 C2H2-type 2; atypical.
 MOD_RES 590 590 Phosphoserine.
 MOD_RES 859 859 Phosphoserine.
 MOD_RES 861 861 Phosphoserine.
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 893 893 Phosphoserine.
 MOD_RES 937 937 Phosphoserine.
 MOD_RES 1021 1021 Phosphothreonine.
 MOD_RES 1025 1025 Phosphoserine.
 MOD_RES 1026 1026 Phosphoserine.
 MOD_RES 1031 1031 Phosphoserine.
 MOD_RES 1279 1279 Phosphoserine.
 MOD_RES 1281 1281 Phosphoserine (By similarity).
 MOD_RES 1284 1284 Phosphoserine.
 MOD_RES 1302 1302 Phosphoserine.
 MOD_RES 1328 1328 Phosphoserine.
 MOD_RES 1370 1370 Phosphoserine.
 MOD_RES 1372 1372 Phosphothreonine.  
Keyword
 Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1883 AA 
Protein Sequence
MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA QEREDDGKGE 60
EEEEDYFDKE LIQLIKQRKE QSRQDEPSNS NQEINSDDRR PQWRREDRIP YQDRESYSQP 120
AWHHRGPPQR DWKWEKDGFN NTRKNSFPHS LRNGGGPRGR SGWHKGVAGG SSTWFHNHSN 180
SGGGWLSNSG AVDWNHNGTG RNSSWLSEGT GGFSSWHMNN SNGNWKSSVR STNNWNYSGP 240
GDKFQPGRNR NSNCQMEDMT MLWNKKSNKS NKYSHDRYNW QRQENDKLGT VATYRGPSEG 300
FTSDKFPSEG LLDFNFEQLE SQTTKQADTA TSKVSGKNGS AAREKPRRWT PYPSQKTLDL 360
QSGLKDITGN KSEMIEKPLF DFSLITTGIQ EPQTDETRNS PTQKTQKEIH TGSLNHKASS 420
DSAASFEVVR QCPTAEKPEQ EHTPNKMPSL KSPLLPCPAT KSLSQKQDPK NISKNTKTNF 480
FSPGEHSNPS NKPTVEDNHG PYISKLRSSC PHVLKGNKST FGSQKQSGDN LNDTLRKAKE 540
VLQCHESLQN PLLSTSKSTR NYAKASRNVE ESEKGSLKIE FQVHALEDES DGETSDTEKH 600
GTKIGTLGSA TTELLSGSTR TADEKEEDDR ILKTSRELST SPCNPIVRQK ESELQMTSAA 660
SPHPGLLLDL KTSLEDAQVD DSIKSHVSYE TEGFESASLD AELQKSDISQ PSGPLLPELS 720
KLGFPASLQR DLTRHISLKS KTGVHLPEPN LNSARRIRNI SGHRKSETEK ESGLKPTLRQ 780
ILNASRRNVN WEQVIQQVTK KKQELGKGLP RFGIEMVPLV QNEQEALDLD GEPDLSSLEG 840
FQWEGVSISS SPGLARKRSL SESSVIMDRA PSVYSFFSEE GTGKENEPQQ MVSPSNSLRA 900
GQSQKATMHL KQEVTPRAAS LRTGERAENV ATQRRHSAQL SSDHIIPLMH LAKDLNSQER 960
SIPPSENQNS QESNGEGNCL SSSASSALAI SSLADAATDS SCTSGAEQND GQSIRKKRRA 1020
TGDGSSPELP SLERKNKRRK IKGKKERSQV DQLLNISLRE EELSKSLQCM DNNLLQARAA 1080
LQTAYVEVQR LLMLKQQITM EMSALRTHRI QILQGLQETY EPSEHPDQVP CSLTRERRNS 1140
RSQTSIDAAL LPTPFFPLFL EPPSSHVSPS PTGASLQITT SPTFQTHGSV PAPDSSVQIK 1200
QEPMSPEQDE NVNAVPPSSA CNVSKELLEA NREISDSCPV YPVITARLSL PESTESFHEP 1260
SQELKFSVEQ RNTRNRENSP SSQSAGLSSI NKEGEEPTKG NSGSEACTSS FLRLSFASET 1320
PLEKEPHSPA DQPEQQAEST LTSAETRGSK KKKKLRKKKS LRAAHVPENS DTEQDVLTVK 1380
PVRKVKAGKL IKGGKVTTST WEDSRTGREQ ESVRDEPDSD SSLEVLEIPN PQLEVVAIDS 1440
SESGEEKPDS PSKKDIWNST EQNPLETSRS GCDEVSSTSE IGTRYKDGIP VSVAETQTVI 1500
SSIKGSKNSS EISSEPGDDD EPTEGSFEGH QAAVNAIQIF GNLLYTCSAD KTVRVYNLVS 1560
RKCIGVFEGH TSKVNCLLVT QTSGKNAALY TGSSDHTIRC YNVKSRECVE QLQLEDRVLC 1620
LHSRWRILYA GLANGTVVTF NIKNNKRLEI FECHGPRAVS CLATAQEGAR KLLVVGSYDC 1680
TISVRDARNG LLLRTLEGHS KTILCMKVVN DLVFSGSSDQ SVHAHNIHTG ELVRIYKGHN 1740
HAVTVVNILG KVMVTACLDK FVRVYELQSH DRLQVYGGHK DMIMCMTIHK SMIYTGCYDG 1800
SIQAVRLNLM QNYRCWWHGC SLIFGVVDHL KQHLLTDHTN PNFQTLKCRW KNCDAFFTAR 1860
KGSKQDAAGH IERHAEDDSK IDS 1883 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008286; P:insulin receptor signaling pathway; IEA:Compara. 
Interpro
 IPR018391; PQQ_beta_propeller_repeat.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF00400; WD40 
SMART
 SM00564; PQQ
 SM00320; WD40
 SM00355; ZnF_C2H2 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS