CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001127
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cullin-associated NEDD8-dissociated protein 2 
Protein Synonyms/Alias
 Cullin-associated and neddylation-dissociated protein 2; Epididymis tissue protein Li 169; TBP-interacting protein of 120 kDa B; TBP-interacting protein 120B; p120 CAND2 
Gene Name
 CAND2 
Gene Synonyms/Alias
 KIAA0667; TIP120B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
588TDLDQEVKERAISCMubiquitination[1]
1173SVKQEFEKQDELKRSacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes (By similarity). 
Sequence Annotation
 REPEAT 2 39 HEAT 1.
 REPEAT 44 81 HEAT 2.
 REPEAT 83 119 HEAT 3.
 REPEAT 129 167 HEAT 4.
 REPEAT 171 208 HEAT 5.
 REPEAT 210 246 HEAT 6.
 REPEAT 254 291 HEAT 7.
 REPEAT 327 368 HEAT 8.
 REPEAT 372 409 HEAT 9.
 REPEAT 432 469 HEAT 10.
 REPEAT 517 554 HEAT 11.
 REPEAT 565 604 HEAT 12.
 REPEAT 608 645 HEAT 13.
 REPEAT 648 685 HEAT 14.
 REPEAT 690 727 HEAT 15.
 REPEAT 731 770 HEAT 16.
 REPEAT 772 813 HEAT 17.
 REPEAT 857 894 HEAT 18.
 REPEAT 896 931 HEAT 19.
 REPEAT 933 966 HEAT 20.
 REPEAT 967 1003 HEAT 21.
 REPEAT 1007 1044 HEAT 22.
 REPEAT 1048 1084 HEAT 23.
 REPEAT 1105 1141 HEAT 24.
 REPEAT 1157 1194 HEAT 25.
 REPEAT 1204 1236 HEAT 26.
 MOD_RES 2 2 N-acetylserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Ubl conjugation; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1236 AA 
Protein Sequence
MSTAAFHISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV KMLLRLLEDK 60
NGEVQNLAVK CLGPLVVKVK EYQVETIVDT LCTNMRSDKE QLRDIAGIGL KTVLSELPPA 120
ATGSGLATNV CRKITGQLTS AIAQQEDVAV QLEALDILSD MLSRLGVPLG AFHASLLHCL 180
LPQLSSPRLA VRKRAVGALG HLAAACSTDL FVELADHLLD RLPGPRVPTS PTAIRTLIQC 240
LGSVGRQAGH RLGAHLDRLV PLVEDFCNLD DDELRESCLQ AFEAFLRKCP KEMGPHVPNV 300
TSLCLQYIKH DPNYNYDSDE DEEQMETEDS EFSEQESEDE YSDDDDMSWK VRRAAAKCIA 360
ALISSRPDLL PDFHCTLAPV LIRRFKEREE NVKADVFTAY IVLLRQTQPP KGWLEAMEEP 420
TQTGSNLHML RGQVPLVVKA LQRQLKDRSV RARQGCFSLL TELAGVLPGS LAEHMPVLVS 480
GIIFSLADRS SSSTIRMDAL AFLQGLLGTE PAEAFHPHLP ILLPPVMACV ADSFYKIAAE 540
ALVVLQELVR ALWPLHRPRM LDPEPYVGEM SAVTLARLRA TDLDQEVKER AISCMGHLVG 600
HLGDRLGDDL EPTLLLLLDR LRNEITRLPA IKALTLVAVS PLQLDLQPIL AEALHILASF 660
LRKNQRALRL ATLAALDALA QSQGLSLPPS AVQAVLAELP ALVNESDMHV AQLAVDFLAT 720
VTQAQPASLV EVSGPVLSEL LRLLRSPLLP AGVLAAAEGF LQALVGTRPP CVDYAKLISL 780
LTAPVYEQAV DGGPGLHKQV FHSLARCVAA LSAACPQEAA STASRLVCDA RSPHSSTGVK 840
VLAFLSLAEV GQVAGPGHQR ELKAVLLEAL GSPSEDVRAA ASYALGRVGA GSLPDFLPFL 900
LEQIEAEPRR QYLLLHSLRE ALGAAQPDSL KPYAEDIWAL LFQRCEGAEE GTRGVVAECI 960
GKLVLVNPSF LLPRLRKQLA AGRPHTRSTV ITAVKFLISD QPHPIDPLLK SFIGEFMESL 1020
QDPDLNVRRA TLAFFNSAVH NKPSLVRDLL DDILPLLYQE TKIRRDLIRE VEMGPFKHTV 1080
DDGLDVRKAA FECMYSLLES CLGQLDICEF LNHVEDGLKD HYDIRMLTFI MVARLATLCP 1140
APVLQRVDRL IEPLRATCTA KVKAGSVKQE FEKQDELKRS AMRAVAALLT IPEVGKSPIM 1200
ADFSSQIRSN PELAALFESI QKDSASAPST DSMELS 1236 
Gene Ontology
 GO:0005622; C:intracellular; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR013932; TATA-bd_TIP120. 
Pfam
 PF08623; TIP120 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS