UniProt Accession

 CRYAB_BOVIN; P02510; O46508; Q3SZQ9 

Genbank Protein ID

 AF029793; BC102745 

Genbank Nucleotide ID

 AAB95323.2; AAI02746.1 

Protein Name

 Alpha-crystallin B chain 

Protein Synonyms/Alias

 Alpha(B)-crystallin 

Gene Name

 CRYAB 

Gene Synonyms/Alias

 CRYA2 

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
90	HFSPEELKVKVLGDV	glycation	[1]
92	SPEELKVKVLGDVIE	glycation	[1]
103	DVIEVHGKHEERQDE	glycation	[2]
150	LTVNGPRKQASGPER	glycation	[2]
166	IPITREEKPAVTAAP	glycation	[3]

Reference

 [1] Site selectivity in the glycation of alpha A- and alpha B-crystallins by glucose.
 Abraham EC, Cherian M, Smith JB.
 Biochem Biophys Res Commun. 1994 Jun 30;201(3):1451-6. [PMID: 7912928]
 [2] Quantification of post-translationally modified peptides of bovine alpha-crystallin using tandem mass tags and electron transfer dissociation.
 Viner RI, Zhang T, Second T, Zabrouskov V.
 J Proteomics. 2009 Jul 21;72(5):874-85. [PMID: 19245863]
 [3] Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of alpha A- and alpha B-crystallins.
 Abraham EC, Huaqian J, Aziz A, Kumarasamy A, Datta P.
 Mol Cell Biochem. 2008 Mar;310(1-2):235-9. [PMID: 18158587] 

Functional Description

 May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. 

Sequence Annotation

 METAL 104 104 Zinc (By similarity).
 METAL 111 111 Zinc (By similarity).
 METAL 119 119 Zinc (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 22 22 Omega-N-methylated arginine (By
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 50 50 Omega-N-methylated arginine (By
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 92 92 N6-acetyllysine; alternate (By
 MOD_RES 166 166 N6-acetyllysine (By similarity).
 CARBOHYD 90 90 N-linked (Glc) (glycation) (Probable).
 CARBOHYD 92 92 N-linked (Glc) (glycation); alternate  

Keyword

 Acetylation; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Eye lens protein; Glycation; Glycoprotein; Metal-binding; Methylation; Nucleus; Oxidation; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0060561; P:apoptotic process involved in morphogenesis; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0032387; P:negative regulation of intracellular transport; ISS:AgBase.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007021; P:tubulin complex assembly; IEA:Compara. 

Interpro

 IPR002068; a-crystallin/Hsp20_dom.
 IPR001436; Alpha-crystallin/HSP.
 IPR012273; Alpha-crystallin_B.
 IPR003090; Alpha-crystallin_N.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF00525; Crystallin
 PF00011; HSP20 

SMART

  

PROSITE

 PS01031; HSP20 

PRINTS

 PR00299; ACRYSTALLIN.