UniProt Accession

 TOM22_YEAST; P49334; D6W151; Q36757 

Genbank Protein ID

 Z46843; X82405; X80348; Z71407; BK006947 

Genbank Nucleotide ID

 CAA86894.1; CAA57799.1; CAA56588.1; CAA96013.1; DAA10417.1 

Protein Name

 Mitochondrial import receptor subunit TOM22 

Protein Synonyms/Alias

 Mitochondrial 17 kDa assembly protein; Mitochondrial 22 kDa outer membrane protein; Protein MAS17; Translocase of outer membrane 22 kDa subunit 

Gene Name

 TOM22 

Gene Synonyms/Alias

 MAS17; MAS22; MOM22; YNL131W; N1217; N1862 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
66	LDRIVALKDIVPPGK	ubiquitination	[1]
145	NILAQGEKDAAATAN	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating. 

Sequence Annotation

 MOD_RES 44 44 Phosphoserine.
 MOD_RES 46 46 Phosphoserine.  

Keyword

 Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Protein transport; Receptor; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD.
 GO:0005742; C:mitochondrial outer membrane translocase complex; IDA:SGD.
 GO:0030150; P:protein import into mitochondrial matrix; IMP:SGD.
 GO:0045040; P:protein import into mitochondrial outer membrane; IMP:SGD. 

Interpro

 IPR005683; Tom22.
 IPR020951; Tom22_fun. 

Pfam

 PF04281; Tom22 

SMART

  

PROSITE

  

PRINTS