CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031690
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor coactivator 1 
Protein Synonyms/Alias
  
Gene Name
 NCOA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
481KYSQTSHKLVQLLTTacetylation[1]
607YLLDKDEKDLRSTPNacetylation[2]
808DRALGIDKLVQGGGLubiquitination[3]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1248 AA 
Protein Sequence
MNTSVYSILH VGDHAEFVKN LLPKSLVNGV PWPQEATRRN SHTFNCRMLI HPPDEPGTEN 60
QEACQRYEVM QCFTVSQPKS IQEDGEDFQS CLICIARRLP RPPAITGVES FMTKQDTTGK 120
IISIDTSSLR AAGRTGWEDL VRKCIYAFFQ PQGREPSYAR QLFQEVMTRG TASSPSYRFI 180
LNDGTMLSAH TKCKLCYPQS PDMQPFIMGI HIIDREHSGL SPQDDTNSGM SIPRVNPSVN 240
PSISPAHGVA RSSTLPPSNS NMVSTRINRQ QSSDLHSSSH SNSSNSQGSF GCSPGSQIVA 300
NVALNQGQAS SQSSNPSLNL NNSPMEGTGI SLAQFMSPRR QVTSGLATRP RMPNNSFPPN 360
ISTLSSPVGM TSSACNNNNR SYSNIPVTSL QGMNEGPNNS VGFSASSPVL RQMSSQNSPS 420
RLNIQPAKAE SKDNKEIASI LNEMIQSDNS SSDGKPLDSG LLHNNDRLSD GDSKYSQTSH 480
KLVQLLTTTA EQQLRHADID TSCKDVLSCT GTSNSASANS SGGSCPSSHS SLTERHKILH 540
RLLQEGSPSD ITTLSVEPDK KDSASTSVSV TGQVQGNSSI KLELDASKKK ESKDHQLLRY 600
LLDKDEKDLR STPNLSLDDV KVKVEKKEQM DPCNTNPTPM TKPTPEEIKL EAQSQFTADL 660
DQFDQLLPTL EKAAQLPGLC ETDRMDGAVT SVTIKSEILP ASLQSATARP TSRLNRLPEL 720
ELEAIDNQFG QPGTGDQIPW TNNTVTAINQ SKSEDQCISS QLDELLCPPT TVEGRNDEKA 780
LLEQLVSFLS GKDETELAEL DRALGIDKLV QGGGLDVLSE RFPPQQATPP LIMEERPNLY 840
SQPYSSPSPT ANLPSPFQGM VRQKPSLGTM PVQVTPPRGA FSPGMGMQPR QTLNRPPAAP 900
NQLRLQLQQR LQGQQQLIHQ NRQAILNQFA ATAPVGINMR SGMQQQITPQ PPLNAQMLAQ 960
RQRELYSQQH RQRQLIQQQR AMLMRQQSFG NNLPPSSGLP VQMGNPRLPQ GAPQQFPYPP 1020
NYGTNPGTPP ASTSPFSQLA ANPEASLANR NSMVSRGMTG NIGGQFGTGI NPQMQQNVFQ 1080
YPGAGMVPQG EANFAPSLSP GSSMVPMPIP PPQSSLLQQT PPASGYQSPD MKAWQQGAIG 1140
NNNVFSQAVQ NQPTPAQPGV YNNMSITVSM AGGNTNVQNM NPMMAQMQMS SLQMPGMNTV 1200
CPEQINDPAL RHTGLYCNQL SSTDLLKTEA DGTQDKKTEE FFSVVTTD 1248 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IEA:InterPro.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR010011; DUF1518.
 IPR009110; Nuc_rcpt_coact.
 IPR014920; Nuc_rcpt_coact_Ncoa-typ.
 IPR000014; PAS.
 IPR014935; SRC-1.
 IPR008955; Src1_rcpt_coact. 
Pfam
 PF07469; DUF1518
 PF08815; Nuc_rec_co-act
 PF08832; SRC-1 
SMART
  
PROSITE
  
PRINTS