| Tag | Content |
|---|
| CPLM ID | CPLM-008069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Desmin |
Protein Synonyms/Alias | |
Gene Name | Des |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 239 | NEEIAFLKKVHEEEI | acetylation | [1] | | 296 | SEAEEWYKSKVSDLT | acetylation | [1] | | 308 | DLTQAANKNNDALRQ | acetylation | [1] | | 317 | NDALRQAKQEMMEYR | acetylation | [1] | | 377 | EEEIRHLKDEMARHL | acetylation | [1] | | 448 | TKKTVMIKTIETRDG | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. |
Sequence Annotation | REGION 1 108 Head.
REGION 109 411 Rod.
REGION 109 140 Coil 1A.
REGION 141 150 Linker 1.
REGION 151 251 Coil 1B.
REGION 252 267 Linker 12.
REGION 268 286 Coil 2A.
REGION 287 294 Linker 2.
REGION 295 411 Coil 2B.
REGION 412 469 Tail.
MOD_RES 12 12 Phosphoserine; by AURKB (By similarity).
MOD_RES 17 17 Phosphothreonine; by AURKB (By
MOD_RES 58 58 ADP-ribosylarginine (Probable).
MOD_RES 60 60 Phosphoserine; by AURKB (By similarity). |
Keyword | ADP-ribosylation; Coiled coil; Complete proteome; Cytoplasm; Intermediate filament; Muscle protein; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 469 AA |
Protein Sequence | MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSVT SRVYQVSRTS 60
GGAGGLGSLR ASRLGTTRAP SYGAGELLDF SLADAVNQEF LATRTNEKVE LQELNDRFAN 120
YFEKVRFLEQ QNAALAAEVN RLKGREPTRV AELYEEEMRE LRRQVEVLTN QRARVDVERD 180
NLIDDLQRLK AKLQEEIQLR EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK 240
VHEEEIRELQ AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS 300
DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE LEDRFASEAS 360
GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE IATYRKLLEG EESRINLPIQ 420
TFSALNFRET SPEQRGSEVH TKKTVMIKTI ETRDGEVVSE ATQQQHEVL 469 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005921; C:gap junction; IDA:BHF-UCL. GO:0045098; C:type III intermediate filament; IDA:RGD. GO:0005198; F:structural molecule activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |