UniProt Accession

 BIK_HUMAN; Q13323; Q16582; Q6FH93 

Genbank Protein ID

 U34584; U49730; X89986; AF174424; AF174421; AF174422; AF174423; CR456390; BT006728; AY245248; CR541863; CR541883; AL022237; CH471138; BC001599 

Genbank Nucleotide ID

 AAC50413.1; AAC79124.1; CAA62013.1; AAF01156.1; AAF01156.1; AAF01156.1; AAF01156.1; CAG30276.1; AAP35374.1; AAO61089.1; CAG46661.1; CAG46681.1; CAA18260.2; EAW73282.1; AAH01599.1 

Protein Name

 Bcl-2-interacting killer 

Protein Synonyms/Alias

 Apoptosis inducer NBK; BIP1; BP4 

Gene Name

 BIK 

Gene Synonyms/Alias

 NBK 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	MDGFTTLKENIMRFW	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. 

Sequence Annotation

 REGION 137 158 Leucine-zipper (Potential).
 MOTIF 57 71 BH3.  

Keyword

 3D-structure; Apoptosis; Complete proteome; Membrane; Mitochondrion; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; TAS:UniProtKB.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0032464; P:positive regulation of protein homooligomerization; IDA:BHF-UCL.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:BHF-UCL.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR024579; Bcl2-int_killer.
 IPR020728; Bcl2_BH3_motif_CS. 

Pfam

 PF12201; bcl-2I13 

SMART

  

PROSITE

 PS01259; BH3 

PRINTS