| Tag | Content |
|---|
| CPLM ID | CPLM-000033 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metabotropic glutamate receptor 8 |
Protein Synonyms/Alias | mGluR8 |
Gene Name | GRM8 |
Gene Synonyms/Alias | GPRC1H; MGLUR8 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 882 | DRPNGEVKSELCESL | sumoylation | [1] | | 903 | SVEFPMVKSGSTS** | sumoylation | [1] |
|
Reference | [1] SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b. Dütting E, Schröder-Kress N, Sticht H, Enz R. Biochem J. 2011 Apr 15;435(2):365-71. [ PMID: 21288202] |
Functional Description | Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. |
Sequence Annotation | CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
CARBOHYD 452 452 N-linked (GlcNAc...) (Potential).
CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).
CARBOHYD 565 565 N-linked (GlcNAc...) (Potential).
DISULFID 64 106 By similarity.
DISULFID 246 534 By similarity.
DISULFID 369 384 By similarity.
DISULFID 424 431 By similarity.
DISULFID 516 535 By similarity.
DISULFID 520 538 By similarity.
DISULFID 541 553 By similarity.
DISULFID 556 569 By similarity.
CROSSLNK 882 882 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Isopeptide bond; Membrane; Olfaction; Polymorphism; Receptor; Reference proteome; Sensory transduction; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 908 AA |
Protein Sequence | MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG LFPVHAKGER 60
GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV RILDTCSRDT YALEQSLTFV 120
QALIEKDASD VKCANGDPPI FTKPDKISGV IGAAASSVSI MVANILRLFK IPQISYASTA 180
PELSDNTRYD FFSRVVPPDS YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR 240
EIGGVCIAQS QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 300
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL ANNRRNVWFA 360
EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG KVQFVIDAVY SMAYALHNMH 420
KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN FNGSAGTPVT FNENGDAPGR YDIFQYQITN 480
KSTEYKVIGH WTNQLHLKVE DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER 540
CEGYNYQVDE LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 600
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF RRVFLGLGMC 660
FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF SLISVQLLGV FVWFVVDPPH 720
IIIDYGEQRT LDPEKARGVL KCDISDLSLI CSLGYSILLM VTCTVYAIKT RGVPETFNEA 780
KPIGFTMYTT CIIWLAFIPI FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI 840
IIFHPEQNVQ KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNSKSSVEFP 900
MVKSGSTS 908 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0004930; F:G-protein coupled receptor activity; TAS:UniProtKB. GO:0008066; F:glutamate receptor activity; TAS:UniProtKB. GO:0001642; F:group III metabotropic glutamate receptor activity; IEA:Compara. GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc. GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW. GO:0007601; P:visual perception; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |