| Tag | Content |
|---|
| CPLM ID | CPLM-014791 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclin-dependent kinase 13 |
Protein Synonyms/Alias | CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13 |
Gene Name | Cdk13 |
Gene Synonyms/Alias | Cdc2l5; Kiaa1791 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1045 | STIKAPRKDLSLGLD | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. |
Sequence Annotation | DOMAIN 705 998 Protein kinase.
NP_BIND 711 719 ATP (By similarity).
ACT_SITE 837 837 Proton acceptor (By similarity).
BINDING 734 734 ATP (By similarity).
MOD_RES 316 316 Phosphoserine (By similarity).
MOD_RES 318 318 Phosphoserine (By similarity).
MOD_RES 326 326 Phosphoserine.
MOD_RES 341 341 Phosphoserine (By similarity).
MOD_RES 343 343 Phosphoserine (By similarity).
MOD_RES 384 384 Phosphoserine.
MOD_RES 396 396 Phosphoserine.
MOD_RES 398 398 Phosphoserine.
MOD_RES 401 401 Phosphoserine.
MOD_RES 410 410 Phosphoserine.
MOD_RES 437 437 Phosphoserine.
MOD_RES 438 438 Phosphoserine.
MOD_RES 440 440 Phosphoserine (By similarity).
MOD_RES 526 526 Phosphoserine (By similarity).
MOD_RES 557 557 N6-acetyllysine (By similarity).
MOD_RES 871 871 Phosphothreonine.
MOD_RES 1048 1048 Phosphoserine (By similarity).
MOD_RES 1245 1245 Phosphothreonine (By similarity). |
Keyword | Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1511 AA |
Protein Sequence | MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 60
LAAPGAAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRPG GRQKRRRGPR AGQEAEKRRV 120
FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGNGGS 180
PASSSGTQRR AEGSERRPRR DRRSSSGRSK ERHREHRRRD GTRSGSEASK ARSRHGHSGE 240
ERAEAAKSGS SSSSGGRRKS ASATSSSSSS RKDRDLKAHR SRTKSSKEPP SAYKEPPKAY 300
REDKSEPKAY RRRQRSLSPL GGRDESPVSH RASQSLRSRK SPSPAGGGSS PYSRRLPRSP 360
SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVLRRSAKS RSRSPYSSRH 420
SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 480
AEAAAKAAKA SNASTPTKGN TETGASVSQT NHVKEVKKLK TEHAPSPSSG GTVKSDKAKT 540
KPPLQVTKVD NNLTVEKATK KTVVGKESKP AATKEEPVST KEKSKPLTPS TGAKEKEQHV 600
ALVTSTLPPL PLPPMLPEDK DADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 660
LSKSPEEKKT AAQLHSKRRP KICGPRYGEI KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 720
KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 780
KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 840
SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 900
GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 960
REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 1020
WSKKRRRQKQ MGMTDDLSTI KAPRKDLSLG LDDSRTNTPQ GVLPPAQLKS QSNSNVAPVI 1080
TGPGQPLNHS ELAILLNLLQ SKSSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE 1140
KQTDPSTPQQ ESSKSLGGVQ PSQTIQPKVE TDAAQAAVQS AFAVLLTQLI KAQQSKQKDA 1200
MLEERENGSG HEAPLQLRPP LEPSTPGSGQ DDLIQHQDRR ILELTPEPDR PRILPPDQRP 1260
PEPPEPPPVT EEDLDYRTEN QHVPTTSSSL TDPHAGVKAA LLQLLAQHQP QDDPKREGGI 1320
DYPTGDTYVP SSDYKDNFGS SFSAAPYVSS DGLGSSSAAA PLEARSFIGN SDIQSLDNYS 1380
TASSHTGGPP QTSAFTESFA SSVAGYGDIY LNAGPMLFSG DKDHRFEYSH GPITVLTNSN 1440
DPSTGPESTH PLPAKMHNYN YGGNLQENPG GPSLMHGQTW TSPAQGPGYS QGYRGHISTS 1500
AGRGRGRGLP Y 1511 |
Gene Ontology | GO:0019908; C:nuclear cyclin-dependent protein kinase holoenzyme complex; IDA:UniProtKB. GO:0016607; C:nuclear speck; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC. GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; ISS:UniProtKB. GO:0000380; P:alternative mRNA splicing, via spliceosome; IDA:UniProtKB. GO:0030097; P:hemopoiesis; ISS:UniProtKB. GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |