UniProt Accession

 PGAM1_RAT; P25113; Q6P0K6 

Genbank Protein ID

 M76591; S63233; BC065582 

Genbank Nucleotide ID

 AAA41834.1; AAB19888.2; AAH65582.1 

Protein Name

 Phosphoglycerate mutase 1 

Protein Synonyms/Alias

 BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B 

Gene Name

 Pgam1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MAAYKLVLIRHG	acetylation	[1]
5	***MAAYKLVLIRHG	ubiquitination	[2]
39	PAGHEEAKRGGQALR	acetylation	[1]
100	GGLTGLNKAETAAKH	ubiquitination	[2]
106	NKAETAAKHGEAQVK	ubiquitination	[2]
113	KHGEAQVKIWRRSYD	ubiquitination	[2]
138	PFYSNISKDRRYADL	acetylation	[1]
157	LPSCESLKDTIARAL	acetylation	[1]
176	EEIVPQIKEGKRVLI	acetylation	[1]
241	GDEETVRKAMEAVAA	ubiquitination	[2]
251	EAVAAQGKVKK****	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. 

Sequence Annotation

 ACT_SITE 11 11 Tele-phosphohistidine intermediate.
 ACT_SITE 186 186
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 26 26 Phosphotyrosine (By similarity).
 MOD_RES 31 31 Phosphoserine (By similarity).
 MOD_RES 92 92 Phosphotyrosine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 251 251 N6-acetyllysine (By similarity).
 MOD_RES 253 253 N6-acetyllysine (By similarity).
 MOD_RES 254 254 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Hydrolase; Isomerase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004083; F:bisphosphoglycerate 2-phosphatase activity; IEA:EC.
 GO:0004082; F:bisphosphoglycerate mutase activity; IEA:EC.
 GO:0004619; F:phosphoglycerate mutase activity; IDA:RGD.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 

Interpro

 IPR013078; His_Pase_superF_clade-1.
 IPR001345; PG/BPGM_mutase_AS.
 IPR005952; Phosphogly_mut1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS