CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-4 
Protein Synonyms/Alias
 cDNA FLJ50837, highly similar to Sorting nexin-4 
Gene Name
 SNX4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54NETGFQLKADSRLKAubiquitination[1, 2, 3]
60LKADSRLKALNATFRubiquitination[2]
79DKRFTDLKHYSDELQubiquitination[1, 2]
108DRLYGVYKVHGNYGRubiquitination[2, 3, 4]
175ALRAVCRKHELMQYDubiquitination[2]
194AQDLASKKQQCEELVubiquitination[2, 3]
211TVRTFSLKGMTTKLFubiquitination[2, 3]
216SLKGMTTKLFGQETPubiquitination[1, 2, 3]
231EQREARIKVLEEQINubiquitination[1, 2]
245NEGEQQLKSKNLEGRubiquitination[1, 2, 3, 5]
256LEGREFVKNAWADIEubiquitination[1, 2]
299IQVWTNAKECFSKM*ubiquitination[2]
304NAKECFSKM******ubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 305 AA 
Protein Sequence
MDPDFVERRR IGLENFLLRI ASHPILCRDK IFYLFLTQEG NWKETVNETG FQLKADSRLK 60
ALNATFRVKN PDKRFTDLKH YSDELQSVIS HLLRVRARVA DRLYGVYKVH GNYGRVFSEW 120
SAIEKEMGDG LQSAGHHMDV YASSIDDILE DEEHYADQLK EYLFYAEALR AVCRKHELMQ 180
YDLEMAAQDL ASKKQQCEEL VTGTVRTFSL KGMTTKLFGQ ETPEQREARI KVLEEQINEG 240
EQQLKSKNLE GREFVKNAWA DIERFKEQKN RDLKEALISY AVMQISMCKK GIQVWTNAKE 300
CFSKM 305 
Gene Ontology
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro. 
Interpro
 IPR001683; Phox. 
Pfam
 PF00787; PX 
SMART
  
PROSITE
 PS50195; PX 
PRINTS