CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate cyclase type 2 
Protein Synonyms/Alias
  
Gene Name
 Adcy2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
272IQRLQGPKAGQMENTubiquitination[1]
551LRTKSQKKRFEEELNubiquitination[1]
572IDGINAQKQWLKSEDubiquitination[1]
590ISLFFYNKNIEKEYRubiquitination[1]
843FLWKNKFKKEREEIEubiquitination[1]
844LWKNKFKKEREEIETubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1095 AA 
Protein Sequence
MWQEAMRRRR YLRDRAEAAA AAAAGGGEGL QRSRDWLYES YYCMSQQHPL IVFLLLIVMG 60
ACLALLAVFF ALGLEVEDHV AFLITVPTAL AIFFAIFILV CIESVFKKLL RVFSLVIWIC 120
LVAMGYLFMC FGGTVSAWDQ VSFFLFIIFV VYTMLPFNMR DAIIASVLTS SSHTIVLSVY 180
LSATPGAKEH LFWQILANVI IFICGNLAGA YHKHLMELAL QQTYRDTCNC IKSRIKLEFE 240
KRQQERLLLS LLPAHIAMEM KAEIIQRLQG PKAGQMENTN NFHNLYVKRH TNVSILYADI 300
VGFTRLASDC SPGELVHMLN ELFGKFDQIA KENECMRIKI LGDCYYCVSG LPISLPNHAK 360
NCVKMGLDMC EAIKKVRDAT GVDINMRVGV HSGNVLCGVI GLQKWQYDVW SHDVTLANHM 420
EAGGVPGRVH ISSVTLEHLN GAYKVEEGDG EIRDPYLKQH LVKTYFVINP KGERRSPQHL 480
FRPRHTLDGA KMRASVRMTR YLESWGAAKP FAHLHHRDSM TTENGKISTT DVPMGQHNFQ 540
NRTLRTKSQK KRFEEELNER MIQAIDGINA QKQWLKSEDI QRISLFFYNK NIEKEYRATA 600
LPAFKYYVTC ACLIFLCIFI VQILVLPKTS ILGFSFGAAF LSLIFILFVC FAGQLLQCSK 660
KASASLLWLL KSSGIIANRP WPRISLTIVT TAIILTMAVF NMFFLSNSEE TTLPTANASN 720
ANVSVPDNQT AILHARNLFF LPYFIYSCIL GLISCSVFLR VNYELKMLIM MVALVGYNII 780
LLHTHAHVLD AYSQVLFQRP GIWKDLKTMG SVSLSIFFIT LLVLGRQSEY YCRLDFLWKN 840
KFKKEREEIE TMENLNRVLL ENVLPAHVAE HFLARSLKNE ELYHQSYDCV CVMFASIPDF 900
KEFYTESDVN KEGLECLRLL NEIIADFDDL LSKPKFSGVE KIKTIGSTYM AATGLSAVPS 960
QEHAQEPERQ YMHIGTMVEF AYALVGKLDA INKHSFNDFK LRVGINHGPV IAGVIGAQKP 1020
QYDIWGNTVN VASRMDSTGV LDKIQVTEET SLILQTLGYT CTCRGIINVK GKGDLKTYFV 1080
NTEMSRSLSQ SNLAS 1095 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0004016; F:adenylate cyclase activity; TAS:MGI.
 GO:0008294; F:calcium- and calmodulin-responsive adenylate cyclase activity; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR009398; Adenylate_cyclase-like. 
Pfam
 PF06327; DUF1053
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS