| Tag | Content |
|---|
| CPLM ID | CPLM-014724 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclic AMP-responsive element-binding protein 3-like protein 3 |
Protein Synonyms/Alias | cAMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H; Processed cyclic AMP-responsive element-binding protein 3-like protein 3 |
Gene Name | CREB3L3 |
Gene Synonyms/Alias | CREBH; HYST1481 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 225 | DEKKLLAKEGITLPT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. |
Sequence Annotation | DOMAIN 243 306 bZIP.
REGION 245 274 Basic motif (By similarity).
REGION 285 306 Leucine-zipper (By similarity).
CARBOHYD 379 379 O-linked (GalNAc...).
CARBOHYD 410 410 N-linked (GlcNAc...) (Potential).
CARBOHYD 413 413 N-linked (GlcNAc...).
CARBOHYD 420 420 N-linked (GlcNAc...).
CARBOHYD 427 427 N-linked (GlcNAc...). |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome; Signal-anchor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix; Unfolded protein response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MNTDLAAGKM ASAACSMDPI DSFELLDLLF DRQDGILRHV ELGEGWGHVK DQQVLPNPDS 60
DDFLSSILGS GDSLPSSPLW SPEGSDSGIS EDLPSDPQDT PPRSGPATSP AGCHPAQPGK 120
GPCLSYHPGN SCSTTTPGPV IQVPEASVTI DLEMWSPGGR ICAEKPADPV DLSPRCNLTV 180
KDLLLSGSSG DLQQHHLGAS YLLRPGAGHC QELVLTEDEK KLLAKEGITL PTQLPLTKYE 240
ERVLKKIRRK IRNKQSAQES RKKKKEYIDG LETRMSACTA QNQELQRKVL HLEKQNLSLL 300
EQLKKLQAIV VQSTSKSAQT GTCVAVLLLS FALIILPSIS PFGPNKTESP GDFAPVRVFS 360
RTLHNDAASR VAADAVPGSE APGPRPEADT TREESPGSPG ADWGFQDTAN LTNSTEELDN 420
ATLVLRNATE GLGQVALLDW VAPGPSTGSG RAGLEAAGDE L 461 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IDA:HPA. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |