| Tag | Content |
|---|
| CPLM ID | CPLM-017180 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein lifeguard 2 |
Protein Synonyms/Alias | Fas apoptotic inhibitory molecule 2; Neural membrane protein 35 |
Gene Name | Faim2 |
Gene Synonyms/Alias | Kiaa0950; Lfg; Lfg2; Nmp35 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MTQGKLSVANKA | ubiquitination | [1] | | 11 | GKLSVANKAPGTEGQ | ubiquitination | [1] | | 26 | QHQANGEKKDAPAVP | ubiquitination | [1] | | 27 | HQANGEKKDAPAVPS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
Sequence Annotation | MOD_RES 39 39 Phosphotyrosine.
CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Apoptosis; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 317 AA |
Protein Sequence | MTQGKLSVAN KAPGTEGQQH QANGEKKDAP AVPSAPPSYE EATSGEGLKA GTFPQGPTAV 60
PLHPSWAYVD PSGSSGYEGG FPAGHHEHFT TFSWDDQKVR RLFIRKVYTI LLVQLLVTLA 120
VVALFTFCDV VKDYVQANPG WYWASYAVFF ATYLTLACCS GPRRHFPWNL ILLTIFTLSM 180
AYLTGMLSSY YNTTSVLLCL VITALVCLSV TIFSFQTKFD FTSCQGVLFV LLMTLFFSGL 240
LLAVLLPFQY VPWLHAVYAV LGAGVFTLFL AFDTQLLMGN RRHSLSPEEY IFGALNIYLD 300
IIYIFTFFLQ LFGTNRE 317 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0045121; C:membrane raft; IDA:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0021681; P:cerebellar granular layer development; IMP:UniProtKB. GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:UniProtKB. GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |