CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008470
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sensor histidine kinase GlrK 
Protein Synonyms/Alias
  
Gene Name
 glrK 
Gene Synonyms/Alias
 yfhK; b2556; JW5407 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
262RHLSHELKTPLASMRacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Activates GlrR by phosphorylation. 
Sequence Annotation
 DOMAIN 256 472 Histidine kinase.
 MOD_RES 259 259 Phosphohistidine; by autocatalysis (By  
Keyword
 ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MKRWPVFPRS LRQLVMLAFL LILLPLLVLA WQAWQSLNAL SDQAALVNRT TLIDARRSEA 60
MTNAALEMER SYRQYCVLDD PTLAKVYQSQ RKRYSEMLDA HAGVLPDDKL YQALRQDLHN 120
LAQLQCNNSG PDAAAAARLE AFASANTEMV QATRTVVFSR GQQLQREIAE RGQYFGWQSL 180
VLFLVSLVMV LLFTRMIIGP VKNIERMINR LGEGRSLGNS VSFSGPSELR SVGQRILWLS 240
ERLSWLESQR HQFLRHLSHE LKTPLASMRE GTELLADQVV GPLTPEQKEV VSILDSSSRN 300
LQKLIEQLLD YNRKQADSAV ELENVELAPL VETVVSAHSL PARAKMMHTD VDLKATACLA 360
EPMLLMSVLD NLYSNAVHYG AESGNICLRS SLHGARVYID VINTGTPIPQ EERAMIFEPF 420
FQGSHQRKGA VKGSGLGLSI ARDCIRRMQG ELYLVDESGQ DVCFRIELPS SKNTK 475 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000155; F:phosphorelay sensor kinase activity; IDA:EcoCyc.
 GO:0046777; P:protein autophosphorylation; IDA:EcoCyc. 
Interpro
 IPR003660; HAMP_linker_domain.
 IPR003594; HATPase_ATP-bd.
 IPR004358; Sig_transdc_His_kin-like_C.
 IPR003661; Sig_transdc_His_kin_sub1_dim/P.
 IPR005467; Sig_transdc_His_kinase_core.
 IPR009082; Sig_transdc_His_kinase_dimeric. 
Pfam
 PF00672; HAMP
 PF02518; HATPase_c
 PF00512; HisKA 
SMART
 SM00387; HATPase_c
 SM00388; HisKA 
PROSITE
 PS50109; HIS_KIN 
PRINTS
 PR00344; BCTRLSENSOR.