UniProt Accession

 A6P3E4_MOUSE; A6P3E4 

Genbank Protein ID

 AC154649; AB219977 

Genbank Nucleotide ID

 BAF69037.1 

Protein Name

 JNK1 beta1 protein kinase 

Protein Synonyms/Alias

 Mitogen-activated protein kinase 8 

Gene Name

 Mapk8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
153	GIIHRDLKPSNIVVK	ubiquitination	[1]
166	VKSDCTLKILDFGLA	ubiquitination	[1]
308	MLVIDASKRISVDEA	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 384 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004705; F:JUN kinase activity; IDA:MGI.
 GO:0048263; P:determination of dorsal identity; ISO:MGI.
 GO:0001503; P:ossification; IMP:MGI.
 GO:0018107; P:peptidyl-threonine phosphorylation; IMP:MGI.
 GO:2001235; P:positive regulation of apoptotic signaling pathway; IGI:MGI.
 GO:2000017; P:positive regulation of determination of dorsal identity; IDA:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0046686; P:response to cadmium ion; IGI:MGI. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR003527; MAP_kinase_CS.
 IPR008351; MAPK_JNK.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS01351; MAPK
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS

 PR01772; JNKMAPKINASE.