UniProt Accession

 ROA2_HUMAN; P22626; A8K064; P22627; Q9UC98; Q9UDJ2 

Genbank Protein ID

 M29064; M29065; U09123; U09120; U09121; U09122; D28877; D28877; AK289429 

Genbank Nucleotide ID

 AAA60271.1; AAA36574.1; AAB60650.1; AAB60650.1; AAB60650.1; AAB60650.1; BAA06031.1; BAA06032.1; BAF82118.1 

Protein Name

 Heterogeneous nuclear ribonucleoproteins A2/B1 

Protein Synonyms/Alias

 hnRNP A2/B1 

Gene Name

 HNRNPA2B1 

Gene Synonyms/Alias

 HNRPA2B1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	VMRDPASKRSRGFGF	ubiquitination	[1]
92	VAREESGKPGAHVTV	ubiquitination	[1]
156	DDHDPVDKIVLQKYH	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. 

Sequence Annotation

 DOMAIN 21 104 RRM 1.
 DOMAIN 112 191 RRM 2.
 REGION 308 347 Nuclear targeting sequence (By
 MOTIF 9 15 Nuclear localization signal (Potential).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 104 104 N6,N6-dimethyllysine.
 MOD_RES 149 149 Phosphoserine.
 MOD_RES 168 168 N6-acetyllysine.
 MOD_RES 173 173 N6-acetyllysine.
 MOD_RES 203 203 Dimethylated arginine; alternate.
 MOD_RES 203 203 Omega-N-methylarginine; alternate.
 MOD_RES 212 212 Phosphoserine.
 MOD_RES 213 213 Dimethylated arginine; alternate.
 MOD_RES 213 213 Omega-N-methylarginine; alternate.
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 236 236 Phosphoserine.
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 324 324 Phosphoserine.
 MOD_RES 331 331 Phosphotyrosine.
 MOD_RES 341 341 Phosphoserine.
 MOD_RES 344 344 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0097157; F:pre-mRNA intronic binding; IEA:Compara.
 GO:0003723; F:RNA binding; IDA:HGNC.
 GO:0043047; F:single-stranded telomeric DNA binding; IDA:HGNC.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IEA:Compara.
 GO:0050658; P:RNA transport; IDA:HGNC. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS