UniProt Accession

 B7Z1K2_HUMAN; B7Z1K2; F2Z2V5 

Genbank Protein ID

 AL353596; AL445190; AK293573 

Genbank Nucleotide ID

 BAH11538.1 

Protein Name

 HBS1-like protein 

Protein Synonyms/Alias

 cDNA FLJ59477, highly similar to HBS1-like protein 

Gene Name

 HBS1L 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	TMDVGMTKFETTTKV	ubiquitination	[1]
148	RFQEITGKLGHFLKQ	ubiquitination	[1]
154	GKLGHFLKQAGFKES	ubiquitination	[1]
159	FLKQAGFKESDVGFI	ubiquitination	[1]
187	SQSSELTKWYKGLCL	ubiquitination	[1]
190	SELTKWYKGLCLLEQ	ubiquitination	[1]
202	LEQIDSFKPPQRSID	ubiquitination	[1]
210	PPQRSIDKPFRLCVS	ubiquitination	[1, 2]
221	LCVSDVFKDQGSGFC	ubiquitination	[1]
296	GCIFCGPKVPIKACT	ubiquitination	[1, 2]
346	RLISVLNKSTGEVTK	ubiquitination	[1, 2, 3]
381	PIALELYKDFKELGR	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 408 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 

Interpro

 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 

Pfam

 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 

SMART

  

PROSITE

  

PRINTS

 PR00315; ELONGATNFCT.