| Tag | Content |
|---|
| CPLM ID | CPLM-018806 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | USP6 N-terminal-like protein |
Protein Synonyms/Alias | Related to the N-terminus of tre; RN-tre |
Gene Name | USP6NL |
Gene Synonyms/Alias | KIAA0019 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | RDLYSKLKHRARGCS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. |
Sequence Annotation | DOMAIN 100 292 Rab-GAP TBC.
MOD_RES 391 391 Phosphoserine.
MOD_RES 396 396 Phosphoserine.
MOD_RES 546 546 Phosphoserine (By similarity).
MOD_RES 582 582 Phosphotyrosine.
MOD_RES 585 585 Phosphoserine.
MOD_RES 642 642 Phosphoserine.
MOD_RES 655 655 Phosphoserine.
MOD_RES 659 659 Phosphoserine.
MOD_RES 673 673 Phosphoserine (By similarity).
MOD_RES 680 680 Phosphoserine.
MOD_RES 716 716 Phosphoserine.
MOD_RES 729 729 Phosphotyrosine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; GTPase activation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 828 AA |
Protein Sequence | MRTEAVVNSQ GQTDYLTKDS DQDVALKLAQ ERAEIVAKYD RGREGAEIEP WEDADYLVYK 60
VTDRFGFLHE EELPDHNVAV ERQKHLEIER TTKWLKMLKG WEKYKNTEKF HRRIYKGIPL 120
QLRGEVWALL LEIPKMKEET RDLYSKLKHR ARGCSPDIRQ IDLDVNRTFR DHIMFRDRYG 180
VKQQSLFHVL AAYSIYNTEV GYCQGMSQIT ALLLMYMNEE DAFWALVKLF SGPKHAMHGF 240
FVQGFPKLLR FQEHHEKILN KFLSKLKQHL DSQEIYTSFY TMKWFFQCFL DRTPFTLNLR 300
IWDIYIFEGE RVLTAMSYTI LKLHKKHLMK LSMEELVEFF QETLAKDFFF EDDFVIEQLQ 360
ISMTELKRAK LDLPEPGKED EYPKKPLGQL PPELQSWGVH HLSNGQRSVG RPSPLASGRR 420
ESGAPHRRHE HSPHPQSRTG TPERAQPPRR KSVEEESKKL KDEADFQRKL PSGPQDSSRQ 480
YNHAAANQNS NATSNIRKEF VPKWNKPSDV SATERTAKYT MEGKGRAAHP ALAVTVPGPA 540
EVRVSNVRPK MKALDAEDGK RGSTASQYDN VPGPELDSGA SVEEALERAY SQSPRHALYP 600
PSPRKHAEPS SSPSKVSNKF TFKVQPPSHA RYPSQLDGEA RGLAHPPSYS NPPVYHGNSP 660
KHFPTANSSF ASPQFSPGTQ LNPSRRPHGS TLSVSASPEK SYSRPSPLVL PSSRIEVLPV 720
DTGAGGYSGN SGSPKNGKLI IPPVDYLPDN RTWSEVSYTY RPETQGQSWT RDASRGNLPK 780
YSAFQLAPFQ DHGLPAVSVD SPVRYKASPA AEDASPSGYP YSGPPPPAYH YRNRDGLSIQ 840
ESVLL 845 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; IDA:UniProtKB. GO:0007030; P:Golgi organization; IMP:UniProtKB. GO:0035526; P:retrograde transport, plasma membrane to Golgi; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |