CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004574
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldo-keto reductase family 1 member C4 
Protein Synonyms/Alias
 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; Chlordecone reductase; CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA 
Gene Name
 AKR1C4 
Gene Synonyms/Alias
 CHDR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75KIADGSVKREDIFYTacetylation[1]
207SKLLDFCKSKDIVLVacetylation[1]
246PVLCALAKKHKQTPAacetylation[1]
270RGVVVLAKSYNEQRIacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. 
Sequence Annotation
 NP_BIND 13 22 NADP (By similarity).
 NP_BIND 217 280 NADP.
 ACT_SITE 55 55 Proton donor (By similarity).
 BINDING 50 50 NADP.
 BINDING 117 117 NADP (By similarity).
 BINDING 117 117 Substrate (By similarity).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ 60
VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM 120
ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP 180
GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV 240
LCALAKKHKQ TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN 300
RNYRYVVMDF LMDHPDYPFS DEY 323 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004033; F:aldo-keto reductase (NADP) activity; TAS:ProtInc.
 GO:0047042; F:androsterone dehydrogenase (B-specific) activity; IEA:EC.
 GO:0047023; F:androsterone dehydrogenase activity; IDA:UniProtKB.
 GO:0015125; F:bile acid transmembrane transporter activity; TAS:ProtInc.
 GO:0047743; F:chlordecone reductase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:UniProtKB.
 GO:0001758; F:retinal dehydrogenase activity; IDA:UniProtKB.
 GO:0008209; P:androgen metabolic process; TAS:ProtInc.
 GO:0006699; P:bile acid biosynthetic process; TAS:Reactome.
 GO:0071395; P:cellular response to jasmonic acid stimulus; IDA:UniProtKB.
 GO:0044597; P:daunorubicin metabolic process; IMP:UniProtKB.
 GO:0044598; P:doxorubicin metabolic process; IMP:UniProtKB.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.