CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040567
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Paxillin 
Protein Synonyms/Alias
  
Gene Name
 Pxn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
125YSFPNKQKSAEPSPTubiquitination[1]
363GVCGACKKPIAGQVVubiquitination[1]
407DGQPYCEKDYHSLFSubiquitination[1]
466DGKAYCRKDYFDMFAubiquitination[1]
540SLCSGCQKPITGRCIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MDDLDALLAD LESTTSHISK RPVFLSEEPP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 60
TVLDPLDQWQ PSGSRYAHQQ PPSPLPVYSS SAKNSSASNT QDGVGSLCSR AGEEEHVYSF 120
PNKQKSAEPS PTVMSSSLGS NLSELDRLLL ELNAVQHSPP GFPADEAESS PPLPGALSPL 180
YGIPENNTPL GGKAGPLVKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG 240
EMSSPQRVTS SQQQTRISAS SATRELDELM ASLSDFKMQG LEQRVDGERP WAASWPPSSR 300
QSSPEGQDEG GFMAQGKTGS SSPPGGLSKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA 360
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH SLFSPRCYYC 420
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA 480
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK 540
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQSCFVKLF C 591 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030159; F:receptor signaling complex scaffold activity; TAS:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000187; P:activation of MAPK activity; IDA:MGI.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IDA:MGI.
 GO:0006928; P:cellular component movement; IMP:MGI.
 GO:0034614; P:cellular response to reactive oxygen species; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IMP:MGI.
 GO:0048041; P:focal adhesion assembly; IDA:MGI.
 GO:0060396; P:growth hormone receptor signaling pathway; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IMP:MGI.
 GO:0030032; P:lamellipodium assembly; IDA:MGI.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI. 
Interpro
 IPR001904; Paxillin.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS
 PR00832; PAXILLIN.