UniProt Accession

 ARF3_HUMAN; P61204; A8K6G8; P16587 

Genbank Protein ID

 M74493; M33384; M74491; AF493882; BT006670; AK291633; CH471111; BC007647; BC007762; BC017565; BC028402 

Genbank Nucleotide ID

 AAA58359.1; AAA83931.1; AAB59425.1; AAM12596.1; AAP35316.1; BAF84322.1; EAW58026.1; AAH07647.1; AAH07762.1; AAH17565.1; AAH28402.1 

Protein Name

 ADP-ribosylation factor 3 

Protein Synonyms/Alias

  

Gene Name

 ARF3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	TTILYKLKLGEIVTT	ubiquitination	[1]
73	WDVGGQDKIRPLWRH	ubiquitination	[1, 2]
127	VLLVFANKQDLPNAM	ubiquitination	[1, 2]
142	NAAEITDKLGLHSLR	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. 

Sequence Annotation

 NP_BIND 24 31 GTP (By similarity).
 NP_BIND 67 71 GTP (By similarity).
 NP_BIND 126 129 GTP (By similarity).
 LIPID 2 2 N-myristoyl glycine (Potential).  

Keyword

 Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate; Nucleotide-binding; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.