UniProt Accession

 BRX1_HUMAN; Q8TDN6; A8K0P5; Q3ZTT4; Q8N453; Q96DH1 

Genbank Protein ID

 AF347667; AY364244; AK289610; CH471119; BC001546; BC036741 

Genbank Nucleotide ID

 AAL83818.1; AAQ76803.1; BAF82299.1; EAW55909.1; AAH01546.2; AAH36741.1 

Protein Name

 Ribosome biogenesis protein BRX1 homolog 

Protein Synonyms/Alias

 Brix domain-containing protein 2 

Gene Name

 BRIX1 

Gene Synonyms/Alias

 BRIX; BXDC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
276	IRSITAAKYREKQQV	acetylation	[1, 2]
276	IRSITAAKYREKQQV	ubiquitination	[3]
326	QWVKPEPKVDLKARK	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for biogenesis of the 60S ribosomal subunit. 

Sequence Annotation

 DOMAIN 60 249 Brix.
 MOD_RES 276 276 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR004154; Anticodon-bd.
 IPR007109; Brix.
 IPR026532; BRX1. 

Pfam

 PF04427; Brix 

SMART

 SM00879; Brix 

PROSITE

 PS50833; BRIX 

PRINTS