CPLM-016720

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-016720

UniProt Accession

ERI3_MOUSE; Q8C460; A2ADW0; A2ADW2; Q149R0; Q68FL7; Q923K5

Genbank Protein ID

AK083017; AK144107; AL645740; AL671520; AL671520; AL645740; AL671520; AL671520; BC079640; BC116685; BC117540; AY029599

Genbank Nucleotide ID

BAC38733.1; BAE25703.1; CAM23618.1; CAM23618.1; CAM27529.1; CAM27529.1; CAM27524.1; CAM27526.1; AAH79640.1; AAI16686.1; AAI17541.1; AAK38347.1

Protein Name

ERI1 exoribonuclease 3

Protein Synonyms/Alias

Prion interactor 1; Prion protein-interacting protein

Gene Name

Eri3

Gene Synonyms/Alias

Pint1; Prnpip; Prnpip1

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
277	KQWINLKKAYSFAMG	acetylation	[1]

Reference

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]

Functional Description

Sequence Annotation

DOMAIN 146 320 Exonuclease.
ACT_SITE 152 152 Proton acceptor (Potential).
ACT_SITE 307 307 Proton acceptor (Potential).
METAL 150 150 Magnesium 1 (By similarity).
METAL 150 150 Magnesium 2 (By similarity).
METAL 152 152 Magnesium 1 (By similarity).
METAL 249 249 Magnesium 2 (By similarity).
METAL 312 312 Magnesium 1 (By similarity).
BINDING 152 152 AMP (By similarity).
BINDING 307 307 AMP (By similarity).

Keyword

Alternative splicing; Complete proteome; Exonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

337 AA

Protein Sequence

MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP ALTDPSASPA 60
ASLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK VLGSHLLSPC GVPELCSIST 120
RKLAAHGFGA AMAAMVPFPP QRYHYFLVLD FEATCDKPQI HPQEIIEFPI LKLNGRTMEI 180
ESTFHMYVQP VVHPQLTPFC TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS 240
IFVTCGDWDL KVMLPGQCHY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL 300
QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF 337

Gene Ontology

GO:0005622; C:intracellular; IEA:InterPro.
GO:0005886; C:plasma membrane; TAS:MGI.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.

Interpro

IPR006055; Exonuclease.
IPR013520; Exonuclease_RNaseT/DNA_pol3.
IPR012337; RNaseH-like_dom.

Pfam

PF00929; RNase_T

SMART

SM00479; EXOIII

PROSITE

PRINTS