UniProt Accession

 G6PD_DROME; P12646; Q27574; Q27872; Q27879; Q27881; Q9VWE2; Q9VWE3 

Genbank Protein ID

 M26674; M26673; U42738; U42739; U42740; U42741; U42742; U42743; U42744; U42745; U42746; U42747; U42748; U42749; U43165; U43166; U43167; U44721; U45985; AE014298; AE014298; AY052079 

Genbank Nucleotide ID

 AAA51463.1; AAA51463.1; AAB02801.1; AAB02802.1; AAB02803.1; AAB02804.1; AAB02805.1; AAB02806.1; AAB02807.1; AAB02808.1; AAB02809.1; AAB02810.1; AAB02811.1; AAB02812.1; AAA99071.1; AAA99072.1; AAA99073.1; AAA99092.1; AAA99107.1; AAF48999.1; AAF49000.2; AAK93503.1 

Protein Name

 Glucose-6-phosphate 1-dehydrogenase 

Protein Synonyms/Alias

 G6PD; Zwischenferment 

Gene Name

 Zw 

Gene Synonyms/Alias

 G6PD; CG12529 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
175	WNRVIIEKPFGRDDA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). 

Sequence Annotation

 NP_BIND 42 49 NADP 1 (By similarity).
 NP_BIND 406 408 NADP 2 (By similarity).
 NP_BIND 426 428 NADP 2 (By similarity).
 REGION 205 209 Substrate binding (By similarity).
 ACT_SITE 267 267 Proton acceptor (By similarity).
 BINDING 76 76 NADP 1 (By similarity).
 BINDING 175 175 NADP 1; via carbonyl oxygen (By
 BINDING 175 175 Substrate (By similarity).
 BINDING 243 243 Substrate (By similarity).
 BINDING 262 262 Substrate (By similarity).
 BINDING 362 362 NADP 2 (By similarity).
 BINDING 365 365 Substrate (By similarity).
 BINDING 370 370 Substrate (By similarity).
 BINDING 371 371 NADP 2 (By similarity).
 BINDING 375 375 NADP 2 (By similarity).
 BINDING 398 398 NADP 2 (By similarity).
 BINDING 400 400 Substrate (By similarity).
 BINDING 492 492 NADP 2 (By similarity).
 BINDING 508 508 NADP 2 (By similarity).
 BINDING 514 514 NADP 2 (By similarity).
 MOD_RES 20 20 Phosphoserine.  

Keyword

 Alternative splicing; Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 524 AA 

Protein Sequence

Gene Ontology

 GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IMP:FlyBase.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001282; G6P_DH.
 IPR019796; G6P_DH_AS.
 IPR022675; G6P_DH_C.
 IPR022674; G6P_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02781; G6PD_C
 PF00479; G6PD_N 

SMART

  

PROSITE

 PS00069; G6P_DEHYDROGENASE 

PRINTS

 PR00079; G6PDHDRGNASE.