UniProt Accession

 GLO2_YEAST; Q05584; D6VSQ4; E9P8T0 

Genbank Protein ID

 Y10292; U51030; AY557739; BK006938 

Genbank Nucleotide ID

 CAA71335.1; AAB64450.1; AAS56065.1; DAA12114.1 

Protein Name

 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme 

Protein Synonyms/Alias

 Glyoxalase II; Glx II 

Gene Name

 GLO2 

Gene Synonyms/Alias

 YDR272W; D9954.5 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
131	DSICYYVKDPTTDER	ubiquitination	[1]
249	LEDPKVQKAAGDTNN	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. 

Sequence Annotation

 REGION 188 190 Substrate (By similarity).
 REGION 268 271 Substrate (By similarity).
 METAL 59 59 Zinc 1 (By similarity).
 METAL 61 61 Zinc 1 (By similarity).
 METAL 63 63 Zinc 2 (By similarity).
 METAL 64 64 Zinc 2 (By similarity).
 METAL 121 121 Zinc 1 (By similarity).
 METAL 144 144 Zinc 1 (By similarity).
 METAL 144 144 Zinc 2 (By similarity).
 METAL 188 188 Zinc 2 (By similarity).
 BINDING 153 153 Substrate (By similarity).
 MOD_RES 257 257 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IMP:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0044262; P:cellular carbohydrate metabolic process; IMP:SGD.
 GO:0006750; P:glutathione biosynthetic process; IEA:InterPro.
 GO:0019243; P:methylglyoxal catabolic process to D-lactate; IDA:SGD. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS