UniProt Accession

 WDR1_RAT; Q5RKI0 

Genbank Protein ID

 AY986483; BC085864 

Genbank Nucleotide ID

 AAX94056.1; AAH85864.1 

Protein Name

 WD repeat-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 Wdr1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
28	KILGGDPKGDNFLYT	acetylation	[1]
81	ASGDISGKLRIWDTT	acetylation	[1]
95	TQKEHILKYEYQPFA	acetylation	[1]
104	EYQPFAGKIKDIAWT	acetylation	[1]
106	QPFAGKIKDIAWTED	acetylation	[1]
115	IAWTEDSKRIAVVGE	acetylation	[1]
182	EGPPFKFKFTIGDHS	acetylation	[1]
219	QIFIYDGKTGEKVCA	acetylation	[1]
256	LLSASGDKTSKIWDV	acetylation	[1]
362	ENDSFSGKGHTNQVS	acetylation	[1]
405	YSGQGVVKLDVQPKC	acetylation	[1]
405	YSGQGVVKLDVQPKC	ubiquitination	[2]
480	SILGATLKDEGKLLE	acetylation	[1]
569	SDPETKVKIQDAHRL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). 

Sequence Annotation

 REPEAT 56 95 WD 1.
 REPEAT 100 143 WD 2.
 REPEAT 144 184 WD 3.
 REPEAT 187 226 WD 4.
 REPEAT 232 271 WD 5.
 REPEAT 318 359 WD 6.
 REPEAT 363 401 WD 7.
 REPEAT 443 482 WD 8.
 REPEAT 487 526 WD 9.
 REPEAT 530 569 WD 10.
 REPEAT 574 606 WD 11.
 MOD_RES 28 28 N6-acetyllysine (By similarity).
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 115 115 N6-acetyllysine (By similarity).
 MOD_RES 238 238 Phosphotyrosine (By similarity).
 MOD_RES 480 480 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 606 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0002102; C:podosome; IEA:UniProtKB-SubCell. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.