UniProt Accession

 ZY11A_HUMAN; Q6WRX3; A6NCK5 

Genbank Protein ID

 AY271826; AC099677 

Genbank Nucleotide ID

 AAQ01753.1 

Protein Name

 Protein zyg-11 homolog A 

Protein Synonyms/Alias

  

Gene Name

 ZYG11A 

Gene Synonyms/Alias

 ZYG11 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
332	SSDFFTTKQGLRVAG	ubiquitination	[1, 2]
469	FDRFDAAKFVMRWLC	ubiquitination	[3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC (By similarity). 

Sequence Annotation

 REPEAT 204 227 LRR 1.
 REPEAT 235 260 LRR 2.
 REPEAT 490 513 LRR 3.  

Keyword

 Alternative splicing; Complete proteome; Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 759 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 

Pfam

  

SMART

  

PROSITE

  

PRINTS