UniProt Accession

 PON2_HUMAN; Q15165; A4D1H7; B2RCP9; B4DJD5; O15114; O15115; O75856; Q5FBX7; Q86YL0 

Genbank Protein ID

 L48513; AF001601; AF001602; AF001603; AB102891; AK291103; AK296029; AK315209; AY210982; AC005021; CH236949; BC040010 

Genbank Nucleotide ID

 AAC41995.1; AAC27944.1; AAC27945.1; AAC27946.1; BAD89420.1; BAF83792.1; BAG58797.1; BAG37646.1; AAO18083.1; AAC62431.1; EAL24131.1; AAH40010.1 

Protein Name

 Serum paraoxonase/arylesterase 2 

Protein Synonyms/Alias

 PON 2; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2 

Gene Name

 PON2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
313	IQNILCEKPTVTTVY	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. 

Sequence Annotation

 ACT_SITE 114 114 Proton acceptor (By similarity).
 METAL 53 53 Calcium 1; catalytic (By similarity).
 METAL 54 54 Calcium 2 (By similarity).
 METAL 116 116 Calcium 2; via carbonyl oxygen (By
 METAL 167 167 Calcium 1; catalytic (By similarity).
 METAL 168 168 Calcium 2 (By similarity).
 METAL 223 223 Calcium 1; catalytic (By similarity).
 METAL 268 268 Calcium 1; catalytic (By similarity).
 METAL 269 269 Calcium 1; catalytic (By similarity).
 CARBOHYD 254 254 N-linked (GlcNAc...).
 CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
 CARBOHYD 323 323 N-linked (GlcNAc...) (Potential).
 DISULFID 42 352 By similarity.  

Keyword

 Alternative splicing; Calcium; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Metal-binding; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0004064; F:arylesterase activity; TAS:ProtInc.
 GO:0042802; F:identical protein binding; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019439; P:aromatic compound catabolic process; IDA:BHF-UCL.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 

Interpro

 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR002640; Arylesterase.
 IPR008364; Paraoxonase2. 

Pfam

 PF01731; Arylesterase 

SMART

  

PROSITE

  

PRINTS

 PR01785; PARAOXONASE.
 PR01787; PARAOXONASE2.