CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein C6orf106 
Protein Synonyms/Alias
  
Gene Name
 C6orf106 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15LDPELMQKFSCLGTTubiquitination[1, 2]
24SCLGTTDKDVLISEFubiquitination[3, 4, 5]
205FNTQPHRKVEGNFNPubiquitination[4, 6]
218NPFASPQKNRQSDENubiquitination[1, 2, 4, 6, 7, 8]
228QSDENNLKDPGGSEFubiquitination[1, 2, 4, 6, 7, 9]
240SEFDSISKNTWAPAPubiquitination[1, 2, 4, 6]
287LSVVTYSKGLHGPYPubiquitination[2, 6, 8]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [8] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [9] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572
Functional Description
  
Sequence Annotation
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 272 272 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 298 AA 
Protein Sequence
MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM TNWNLQAAIG 60
AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFVKTWR IQNSGAEAWP PGVCLKYVGG 120
DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS RAGMYQGQWR MCTATGLYYG DVIWVILSVE 180
VGGLLGVTQQ LSSFETEFNT QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK 240
NTWAPAPDTW APAPDQTEQD QNRLSQNSVN LSPSSHANNL SVVTYSKGLH GPYPFGQS 298 
Gene Ontology
  
Interpro
 IPR009060; UBA-like. 
Pfam
  
SMART
  
PROSITE
  
PRINTS