CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008278
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab GDP dissociation inhibitor alpha 
Protein Synonyms/Alias
 Rab GDI alpha; Guanosine diphosphate dissociation inhibitor 1; GDI-1 
Gene Name
 Gdi1 
Gene Synonyms/Alias
 Rabgdia 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
54TPLEELYKRFQILEGubiquitination[1]
112VEGSFVYKGGKIYKVacetylation[2]
137NLMGMFEKRRFRKFLacetylation[2]
210LETINRIKLYSESLAacetylation[2]
210LETINRIKLYSESLAubiquitination[1]
221ESLARYGKSPYLYPLubiquitination[1]
269NGKVVGVKSEGEVARacetylation[2]
269NGKVVGVKSEGEVARubiquitination[1]
278EGEVARCKQLICDPSubiquitination[1]
435AFDFENMKRKQNDVFubiquitination[1]
437DFENMKRKQNDVFGEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. 
Sequence Annotation
 MOD_RES 339 339 Phosphotyrosine.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; GTPase activation; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 447 AA 
Protein Sequence
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE ELYKRFQILE 60
GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVVEGSFV YKGGKIYKVP 120
STETEALASN LMGMFEKRRF RKFLVFVANF DENDPKTFEG VDPQNTSMRD VYRKFDLGQD 180
VIDFTGHALA LYRTDDYLDQ PCLETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR 240
LSAIYGGTYM LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VQKAGQVIRI 300
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI AIASTTVETA 360
EPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGSESQVFC SCSYDATTHF ETTCNDIKDI 420
YKRMAGSAFD FENMKRKQND VFGEADQ 447 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005093; F:Rab GDP-dissociation inhibitor activity; IEA:Compara.
 GO:0050771; P:negative regulation of axonogenesis; ISS:UniProtKB.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IEA:Compara. 
Interpro
 IPR018203; GDP_dissociation_inhibitor.
 IPR016040; NAD(P)-bd_dom.
 IPR000806; RabGDI. 
Pfam
 PF00996; GDI 
SMART
  
PROSITE
  
PRINTS
 PR00892; RABGDI.
 PR00891; RABGDIREP.